ArticleeLife2022
Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Comparative connectomics reveals stage-specific gap junction rewiring that reshapes avoidance behavior.bioRxiv : the preprint server for biology · 2026Article
- Volume electron microscopy reveals bacterial endosymbiosis within host mitochondria.Communications biology · 2026Article
- Comprehensive multiomics analyses identify guanylate cyclase activator 1A as a photoreceptor-specific target in a murine model of oxygen-induced retinopathy.Journal of translational medicine · 2026Article
- Rod photoreceptors control the ON vs OFF polarity of cone-signaling neurons.Communications biology · 2026Article
- Functional OCT with parfocal retinal stimulation enables multi-site optoretinography under a single dark adaptation.Biomedical optics express · 2026Article
- Retinal Cx36 gap junctions in the inner and outer plexiform layers differentially control visual thresholds.iScience · 2026Article
- Decoding the roles of bipolar, amacrine, and horizontal cells.Handbook of clinical neurology · 2026Review
- Retinal Neurochemistry.Brain sciences · 2025Review
- Photoreceptor degeneration induces homeostatic rewiring of rod bipolar cells.Current biology : CB · 2025Article
- A pupillary contrast response in mice and humans: Neural mechanisms and visual functions.Neuron · 2024Article
- The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Ultrastructural Characteristics and Synaptic Connectivity of Photoreceptors in the Simplex Retina of Little Skate (eNeuro · 2023Article
- Prenylation is essential for the enrichment of cone phosphodiesterase-6 (PDE6) in outer segments and efficient cone phototransduction.Human molecular genetics · 2023Article
- Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function.Progress in retinal and eye research · 2023Review
- New insights into retinal circuits through EM connectomics: what we have learnt and what remains to be learned.Frontiers in ophthalmology · 2023Review
- When microscopy and electrophysiology meet connectomics-Steve Massey's contribution to unraveling the structure and function of the rod/cone gap junction.Frontiers in ophthalmology · 2023Review
- Stephen Massey: a career in visual neuroscience.Frontiers in ophthalmology · 2023Review
- Single opsin driven white noise ERGs in mice.Frontiers in neuroscience · 2023Article
- Rod-cone signal interference in the retina shapes perception in primates.Frontiers in ophthalmology · 2023Article
- Characterizing the rod pathway in cone-dominated thirteen-lined ground squirrels.Frontiers in ophthalmology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Electrical coupling, mediated by gap junctions, contributes to signal averaging, synchronization, and noise reduction in neuronal circuits. In addition, gap junctions may also provide alternative neuronal pathways. However, because they are small and especially difficult to image, gap junctions are often ignored in large-scale 3D reconstructions. Here, we reconstruct gap junctions between photoreceptors in the mouse retina using serial blockface-scanning electron microscopy, focused ion beam-scanning electron microscopy, and confocal microscopy for the gap junction protein Cx36. An exuberant spray of fine telodendria extends from each cone pedicle (including blue cones) to contact 40-50 nearby rod spherules at sites of Cx36 labeling, with approximately 50 Cx36 clusters per cone pedicle and 2-3 per rod spherule. We were unable to detect rod/rod or cone/cone coupling. Thus, rod/cone coupling accounts for nearly all gap junctions between photoreceptors. We estimate a mean of 86 Cx36 channels per rod/cone pair, which may provide a maximum conductance of ~1200 pS, if all gap junction channels were open. This is comparable to the maximum conductance previously measured between rod/cone pairs in the presence of a dopamine antagonist to activate Cx36, suggesting that the open probability of gap junction channels can approach 100% under certain conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.