Evidence map›Paper›PMID 35471146›Full record

ArticleeLife2022

Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity.

Xinrui L Zhang, William C Spencer, Nobuko Tabuchi, Meagan M Kitt, Evan S Deneris

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xinrui L Zhang *Department of Neurosciences, Case Western Reserve University, Cleveland, United States.ORCID 0000-0002-7728-6970
William C Spencer *Department of Neurosciences, Case Western Reserve University, Cleveland, United States.ORCID 0000-0002-9700-8011
Nobuko TabuchiDepartment of Neurosciences, Case Western Reserve University, Cleveland, United States.
Meagan M KittDepartment of Neurosciences, Case Western Reserve University, Cleveland, United States.
Evan S DenerisDepartment of Neurosciences, Case Western Reserve University, Cleveland, United States.ORCID 0000-0003-4211-9934
Case Western Reserve University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
PET 1 ETS FACTOR IN THE MAMMALIAN 5 HT SYSTEMR01MH062723 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI DENERIS, EVAN S · 2001 to 2021
$8.3M
GRADUATE TRAINING IN CELLULAR AND MOLECULAR BIOLOGYT32GM008056 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI DIEHL, JOHN ALAN, SNIDER, MARTIN D · 1985 to 2019
$7.1M
Gene regulatory mechanisms controlling development of serotonin neuron subtypesR01MH125918 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI DENERIS, EVAN S · 2021 to 2025
$2.9M
Brain serotonin neuron gene regulatory networks and chromatin architectureR01MH117643 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI DENERIS, EVAN S · 2019 to 2024
$2.2M
Regulation of Pet1/FEV binding and chromatin accessibility during serotonergic neuron developmentF30MH122173 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI ZHANG, XINRUI · 2020 to 2023
$206k
NIGMS NIH HHS T32 GM007250NIGMS NIH HHS T32 GM008056NIMH NIH HHS F30 MH122173NIMH NIH HHS R01 MH062723NIMH NIH HHS R01 MH117643NIMH NIH HHS R01 MH125918
6 · The paper itself

Abstract

Assembly of transcriptomes encoding unique neuronal identities requires selective accessibility of transcription factors to cis-regulatory sequences in nucleosome-embedded postmitotic chromatin. Yet, the mechanisms controlling postmitotic neuronal chromatin accessibility are poorly understood. Here, we show that unique distal enhancers define the

Indexed as

ChromatinSerotoninAnimalsMiceNeuronsRegulatory Sequences, Nucleic AcidTranscription FactorsChromatinSerotoninTranscription FactorschromatingeneticsgenomicsLmx1bmouseneuronal maturationneurosciencePet1serotonin neuronsingle cellsynapsetranscription factor

Identifiers

PMID35471146
PMCPMC9098219
OpenAlexW4224948682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.