ArticleRadiology2022
Quantitative MRI Characterization of the Extremely Preterm Brain at Adolescence: Atypical versus Neurotypical Developmental Pathways.
Open access · greenAbstract readMulticenter Study
In one paragraph
Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 24 citations in OpenAlex.
- Neonatal inflammation predicts adolescent brain volume and neurologic outcomes in children born extremely prematurely.Scientific reports · 2026Article
- Regularization by neural style transfer for MRI field-transfer reconstruction with limited data.Frontiers in artificial intelligence · 2025Article
- 3D MR fingerprinting-derived myelin water fraction characterizing brain development and leukodystrophy.Journal of translational medicine · 2023Article
- Primary Multiparametric Quantitative Brain MRI: State-of-the-Art Relaxometric and Proton Density Mapping Techniques.Radiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Ryan McNaughtonFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).ORCID 0000-0002-0584-4435
Chris PieperFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).ORCID 0000-0003-1875-9245
Osamu SakaiFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).ORCID 0000-0003-3462-5116
Julie V RollinsFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).
Xin ZhangFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).ORCID 0000-0002-4413-5084
David N KennedyFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).
Jean A FrazierFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).
Laurie DouglassFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).
Timothy HeerenFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).ORCID 0000-0001-5643-3559
Rebecca C FryFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).
T Michael O'SheaFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).
Karl K KubanFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).ORCID 0000-0001-5299-3567
Hernán JaraFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).ORCID 0000-0001-6395-3819
ELGAN-ECHO Study InvestigatorsFrom the Departments of Mechanical Engineering (R.M., X.Z.) and Biomedical Engineering (H.J.), Boston University College of Engineering, Boston, Mass; Department of Radiology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118 (C.P., O.S., H.J.); Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC (J.V.R., T.M.O.); Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (D.N.K., J.A.F.); Department of Pediatrics, Boston University School of Medicine, Boston, Mass (L.D.); Department of Biostatistics, Boston University School of Public Health, Boston, Mass (T.H.); and Department of Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC (R.C.F.).
Boston University · USUniversity of North Carolina at Chapel Hill · USUniversity of Massachusetts Chan Medical School · US
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MNeonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain DisordersU01NS040069 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI KUBAN, KARL · 2001 to 2014
$34.0MSYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2MThe Role of the Placenta-Brain Axis in Children's NeurodevelopmentUH3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Rebecca Fry, Michael O'SHEA · 2018 to 2026
$21.9MResource DiscoveryP41EB019936 · NIBIB · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI David Nelson Kennedy · 2016 to 2026
$15.2MEnvironment, Epigenetics, Neurodevelopment & Health of Extremely Preterm ChildrenUG3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA, O'SHEA, MICHAEL · 2016 to 2024
$7.4MExposing the Deep Content of the Publication: Knowledge Extraction for Neuroimaging in Child PsychiatryR01MH083320 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FRAZIER, JEAN A, KENNEDY, DAVID NELSON · 2009 to 2020
$6.3MNeuroimaging Informatics Tools and Resources Collaboratory: Outreach, Infrastructure and MaintenanceR24EB029173 · NIBIB · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Christian Haselgrove, David Nelson Kennedy · 2019 to 2026
$5.6MABCD Course on Reproducible Data AnalysesR25DA051675 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI KENNEDY, DAVID NELSON, LAIRD, ANGELA R · 2020 to 2021
$286kNIBIB NIH HHS P41 EB019936NIBIB NIH HHS R24 EB029173NICHD NIH HHS P30 HD018655NIDA NIH HHS R25 DA051675NIEHS NIH HHS P30 ES010126NIH HHS UH3 OD023348NIMH NIH HHS R01 MH083320NINDS NIH HHS U01 NS040069
Abstract
Background Extremely preterm (EP) birth is associated with higher risks of perinatal white matter (WM) injury, potentially causing abnormal neurologic and neurocognitive outcomes. MRI biomarkers distinguishing individuals with and without neurologic disorder guide research on EP birth antecedents, clinical correlates, and prognoses. Purpose To compare multiparametric quantitative MRI (qMRI) parameters of EP-born adolescents with autism spectrum disorder, cerebral palsy, epilepsy, or cognitive impairment (ie, atypically developing) with those without (ie, neurotypically developing), characterizing sex-stratified brain development. Materials and Methods This prospective multicenter study included individuals aged 14-16 years born EP (Extremely Low Gestational Age Newborns-Environmental Influences on Child Health Outcomes Study, or ELGAN-ECHO). Participants underwent 3.0-T MRI evaluation from 2017 to 2019. qMRI outcomes were compared for atypically versus neurotypically developing adolescents and for girls versus boys. Sex-stratified multiple regression models were used to examine associations between spatial entropy density (SE
Indexed as
Autism Spectrum DisorderInfant, Extremely PrematureAdolescentBrainChildFemaleHumansInfant, NewbornMagnetic Resonance ImagingMaleProspective StudiesProtonsProtons
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.