Evidence map›Paper›PMID 35471087›Full record

ArticleJournal of feline medicine and surgery2022

Evaluation of potential thiamazole exposure of owners of orally treated hyperthyroid cats.

Gaëlle Schils, Ellen De Paepe, Bruno Lapauw, Ellen Vanden Broecke, Laurens Van Mulders, Lynn Vanhaecke, Aurélie Lyssens, Lisa Stammeleer, Sylvie Daminet

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of feline medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gaëlle SchilsSmall Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.ORCID 0000-0002-7013-0500
Ellen De PaepeLaboratory of Chemical Analysis, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Bruno LapauwDepartment of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent, Belgium.
Ellen Vanden BroeckeSmall Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Laurens Van MuldersSmall Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Lynn VanhaeckeLaboratory of Chemical Analysis, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Aurélie LyssensDepartment of Clinical Sciences, School of Veterinary Medicine, Liège University, Liège, Belgium.
Lisa StammeleerSmall Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.ORCID 0000-0002-9767-9384
Sylvie DaminetSmall Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Ghent University · BEGhent University Hospital · BEUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe objective of this study was to evaluate the presence of traces of thiamazole in the urine of owners of hyperthyroid cats treated with antithyroid drugs.

methodsUrine was collected from 24 owners of hyperthyroid cats, five human patients treated with thiamazole and five healthy humans without any contact with antithyroid drugs. All owners of hyperthyroid cats were asked to fill out a questionnaire. Urine of hyperthyroid cats was collected by spontaneous micturition. All urine samples were stored at -20°C until analysis by ultra-high-performance liquid chromatography coupled to high-resolution quadrupole Orbitrap mass spectrometry.

resultsThese owners were assessed to have a lot of contact with their cat. Adherence to antithyroid medication handling guidelines was rather poor. High concentrations of thiamazole were detected in all feline samples (median concentration 2818 ng/ml; range 104-15,127) and in the urine of all human patients treated with thiamazole (median concentration 4153 ng/ml; range 1826-5009). No thiamazole was detected in the urine of owners of hyperthyroid cats (limit of detection 3.88 ng/ml; limit of quantification 11.75 ng/ml). CONCLUSIONS AND RELEVANCE: The results regarding the potential exposure of owners of hyperthyroid cats to antithyroid drugs are reassuring. Nevertheless, prudence is still warranted when administering antithyroid drugs. Whether these results can be extrapolated to the use of transdermal application requires further investigation.

Indexed as

Cat DiseasesHyperthyroidismAdministration, CutaneousAnimalsAntithyroid AgentsCatsHumansMethimazoleSurveys and QuestionnairesAntithyroid AgentsMethimazoleantithyroidchromatographyHyperthyroidismteratogenicthiamazole

Identifiers

PMID35471087
PMCPMC11104250
OpenAlexW4224940359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.