Evidence map›Paper›PMID 35471041›Full record

ArticleAntimicrobial agents and chemotherapy2022

The Set1 Histone H3K4 Methyltransferase Contributes to Azole Susceptibility in a Species-Specific Manner by Differentially Altering the Expression of Drug Efflux Pumps and the Ergosterol Gene Pathway.

Kortany M Baker, Smriti Hoda, Debasmita Saha, Justin B Gregor, Livia Georgescu, Nina D Serratore, Yueping Zhang, Lizhi Cheng, Nadia A Lanman, Scott D Briggs

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Set202 is a histone lysine methyltransferase that enablesbioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Does the use of topical azoles have an impact on antifungal resistance?The Journal of antimicrobial chemotherapy · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. HPathogens (Basel, Switzerland) · 2024
    Review
  10. mSphere · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Molecular mechanisms governing antifungal drug resistance.npj antimicrobials and resistance · 2023
    Review
  17. Epigenetic Regulation of Antifungal Drug Resistance.Journal of fungi (Basel, Switzerland) · 2022
    Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kortany M BakerDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Smriti HodaDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Debasmita SahaDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Justin B GregorDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Livia GeorgescuDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Nina D SerratoreDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Yueping ZhangDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Lizhi ChengDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Nadia A LanmanPurdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA.
Scott D BriggsDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0003-2852-3594
Purdue University West Lafayette · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
SET Domain Epigenetic Factors Govern Antifungal Drug Efficacy and Fungal PathogenesisR01AI136995 · NIAID · PURDUE UNIVERSITY · PI BRIGGS, SCOTT D · 2018 to 2022
$1.9M
HHS | NIH | National Cancer Institute (NCI) P30CA023168HHS | NIH | National Cancer Institute (NCI) P30CA082709HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI136995NCI NIH HHS P30 CA023168NIAID NIH HHS R01 AI136995
6 · The paper itself

Abstract

Fungal infections are a major health concern because of limited antifungal drugs and development of drug resistance.

Indexed as

AzolesSaccharomyces cerevisiae ProteinsAntifungal AgentsCandida glabrataDrug Resistance, FungalErgosterolGene Expression Regulation, FungalHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesMicrobial Sensitivity TestsSaccharomyces cerevisiaeAntifungal AgentsAzolesErgosterolHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesSaccharomyces cerevisiae ProteinsSET1 protein, S cerevisiaeantifungal resistanceazoleCandida glabrataepigeneticsERG11ergosterolH3K4 methylationhistone methylationregulation of gene expressionSet1

Identifiers

PMID35471041
PMCPMC9112889
OpenAlexW4224942195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.