Evidence map›Paper›PMID 35470960›Full record

ArticleCNS neuroscience & therapeutics2022

The effect of cannabinoid receptor agonist WIN 55,212-2 on anxiety-like behavior and locomotion in a genetic model of absence seizures in the elevated plus-maze.

Daniel Cassar, Manuela Radic, Maurizio Casarrubea, Vincenzo Crunelli, Giuseppe Di Giovanni

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Daniel CassarLaboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Manuela RadicLaboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Maurizio CasarrubeaLaboratory of Behavioral Physiology, Human Physiology Section "Giuseppe Pagano", Department of Biomedicine, Neuroscience and Advanced Diagnosistics (BIND), University of Palermo, Palermo, Italy.ORCID 0000-0002-3278-6621
Vincenzo CrunelliNeuroscience Division, School of Biosciences, Cardiff University, Cardiff, UK.ORCID 0000-0001-7154-9752
Giuseppe Di GiovanniLaboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.ORCID 0000-0003-2006-563X
University of Malta · MTCardiff University · GBUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GAERS and NEC rats were treated with cannabinoid 1/2 receptor agonist WIN 55,212-2 2 mg/kg and tested on the Elevated Plus-Maze.

Indexed as

Cannabinoid Receptor AgonistsEpilepsy, AbsenceAnimalsAnxietyBenzoxazinesElevated Plus Maze TestLocomotionModels, GeneticMorpholinesNaphthalenesRatsRats, WistarSeizures(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanoneBenzoxazinesCannabinoid Receptor AgonistsMorpholinesNaphthalenes

Identifiers

PMID35470960
PMCPMC9253729
OpenAlexW4224942851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.