Evidence map›Paper›PMID 35470924›Full record

Observational studyJournal of the European Academy of Dermatology and Venereology : JEADV2022

Care pathways in atopic dermatitis: a retrospective population-based cohort study.

L von Kobyletzki, N Ballardini, D Henrohn, M P Neary, G Ortsäter, K Geale, A Rieem Dun, I Lindberg, A De Geer, P Neregård and 4 more

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Journal of the European Academy of Dermatology and Venereology : JEADV, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Review
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  7. Observational
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

L von KobyletzkiDepartment of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-3094-9685
N BallardiniInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-6759-346X
D HenrohnPfizer AB, Sollentuna, Sweden.ORCID https://orcid.org/0000-0001-9514-1153
M P NearyPfizer Inc., New York, NY, USA.ORCID https://orcid.org/0000-0002-8584-3677
G OrtsäterQuantify Research, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-5102-3358
K GealeQuantify Research, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-7241-8471
A Rieem DunQuantify Research, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-8182-5682
I LindbergQuantify Research, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-6549-6065
A De GeerPfizer AB, Sollentuna, Sweden.ORCID https://orcid.org/0000-0002-5327-3198
P NeregårdPfizer AB, Sollentuna, Sweden.ORCID https://orcid.org/0000-0001-9115-3878
A ChaPfizer Inc., New York, NY, USA.
J C CappelleriPfizer Inc., New York, NY, USA.ORCID https://orcid.org/0000-0001-9586-0748
W RomeroInflammation & Immunology, Pfizer Ltd, Surrey, UK.ORCID https://orcid.org/0000-0002-5573-0110
J P ThyssenDepartment of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-3770-1743
Quantify Research (Sweden) · SEPfizer (United States) · USPfizer (Sweden) · SEKarolinska Institutet · SELund University · SEPfizer (United Kingdom) · GBUniversity of Copenhagen · DKUppsala University · SE

Funding

Pfizer GPP3
6 · The paper itself

Abstract

backgroundAtopic dermatitis (AD) is a complex disease with variations in severity and healthcare utilization. Examining patient pathways through analyses of longitudinal patient data provides an opportunity to describe real-world clinical patient care and evaluate healthcare access and treatment.

objectiveTo describe longitudinal care pathways including health care management, treatment patterns and disease progression (by proxy measures) in patients with AD. MATERIALS AND

methodsThis was a longitudinal observational study, which used linked data from national and regional healthcare registers in Sweden. Patients with AD were identified through diagnosis in primary or secondary care or by dispensed medications. Descriptive statistics for number of healthcare visits, type of dispensed drug class, rate of - and time to - referral to secondary care and treatment escalation were calculated.

resultsA total of 341 866 patients with AD distributed as 197 959 paediatric (age < 12), 36 133 adolescent (age ≥ 12- < 18) and 107 774 adult (age ≥ 18) patients were included in this study. Healthcare visits to primary and secondary care and dispensation of AD-indicated treatments were more common during the year in which managed AD care was initiated. Topical corticosteroids (TCSs) and emollients were the most frequently used treatments across all age cohorts while systemic treatment was uncommon in all age cohorts. Among patients who initiated treatment with TCSs, 18.2% escalated to TCSs with higher potency following the start of managed AD care.

conclusionsWe found that healthcare contacts and use of AD-indicated treatments were concentrated in the year during which managed AD care was initiated and decreased significantly thereafter. Since a significant proportion of patients with AD have flares and persistent AD, our results suggest that patients with AD may be monitored infrequently and are undertreated. There is a need to inform practitioners about adequate treatment options to provide individualized care, in particular for patients with persistent severe AD.

Indexed as

Dermatitis, AtopicDermatologic AgentsAdolescentAdultChildCohort StudiesCritical PathwaysEmollientsGlucocorticoidsHumansRetrospective StudiesDermatologic AgentsEmollientsGlucocorticoids

Identifiers

PMID35470924
PMCPMC9542393
OpenAlexW4224440663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.