Evidence map›Paper›PMID 35470904›Full record

ArticleBirth (Berkeley, Calif.)2022

Perinatal outcomes of women with gestational breast cancer in Australia and New Zealand: A prospective population-based study.

Elizabeth Sullivan, Nadom Safi, Zhuoyang Li, Marc Remond, Tina Y T Chen, Nasrin Javid, Jan E Dickinson, Angela Ives, Karin Hammarberg, Antoinette Anazodo and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Birth (Berkeley, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Elizabeth SullivanCollege of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.
Nadom SafiCollege of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0001-8473-0980
Zhuoyang LiCollege of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.
Marc RemondCollege of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.
Tina Y T ChenFaculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.
Nasrin JavidFaculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.
Jan E DickinsonFaculty of Health and Medical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Angela IvesFaculty of Health and Medical Sciences, Medical School, The University of Western Australia, Perth, Western Australia, Australia.
Karin HammarbergSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Antoinette AnazodoSchool of Women and Children, University of New South Wales, Sydney, New South Wales, Australia.
Frances BoylePatricia Ritchie Centre for Cancer Care and Research, Mater Hospital Sydney, and University of Sydney, Sydney, New South Wales, Australia.
Jane FisherSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Lesley HallidaySchool of Public Health and Community Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Greg DuncombeFaculty of Medicine, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia.
Claire McLintockNational Women's Health, Auckland City Hospital, Auckland, New Zealand.
Alex Y WangFaculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.
Christobel SaundersFaculty of Health and Medical Sciences, The University of Western Australia, Perth, Western Australia, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the epidemiology, clinical management, and outcomes of women with gestational breast cancer (GBC).

methodsA population-based prospective cohort study was conducted in Australia and New Zealand between 2013 and 2014 using the Australasian Maternity Outcomes Surveillance System (AMOSS). Women who gave birth with a primary diagnosis of breast cancer during pregnancy were included. Data were collected on demographic and pregnancy factors, GBC diagnosis, obstetric and cancer management, and perinatal outcomes. The main outcome measures were preterm birth, maternal complications, breastfeeding, and death.

resultsForty women with GBC (incidence 7.5/100 000 women giving birth) gave birth to 40 live-born babies. Thirty-three (82.5%) women had breast symptoms at diagnosis. Of 27 women diagnosed before 30 weeks' gestation, 85% had breast surgery and 67% had systemic therapy during pregnancy. In contrast, all 13 women diagnosed from 30 weeks had their cancer management delayed until postdelivery. There were 17 preterm deliveries; 15 were planned. Postpartum complications included the following: hemorrhage (n = 4), laparotomy (n = 1), and thrombocytopenia (n = 1). There was one late maternal death. Eighteen (45.0%) women initiated breastfeeding, including 12 of 23 women who had antenatal breast surgery. There were no perinatal deaths or congenital malformations, but 42.5% of babies were preterm, and 32.5% were admitted for higher-level neonatal care.

conclusionsGestational breast cancer diagnosed before 30 weeks' gestation was associated with surgical and systemic cancer care during pregnancy and planned preterm birth. In contrast, cancer treatment was deferred to postdelivery for women diagnosed from 30 weeks, reflecting the complexity of managing expectant mothers with GBC in multidisciplinary care settings.

Indexed as

Breast NeoplasmsPregnancy Complications, NeoplasticPregnancy OutcomeAustraliaBreast FeedingCesarean SectionFemaleHumansIncidenceInfant, NewbornNew ZealandPregnancyPremature BirthProspective StudiesTime-to-Treatmentbreast cancerbreastfeedingbreast surgerypregnancypretermsystemic therapy

Identifiers

PMID35470904
PMCPMC9790712

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.