Evidence map›Paper›PMID 35470760›Full record

ArticleOphthalmic genetics2022

The role of motor proteins in photoreceptor protein transport and visual function.

Rakesh Radhakrishnan, Venkateshwara R Dronamraju, Matthias Leung, Andrew Gruesen, Ashish K Solanki, Stephen Walterhouse, Heidi Roehrich, Grace Song, Rafael da Costa Monsanto, Sebahattin Cureoglu and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmic genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Rakesh RadhakrishnanDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Venkateshwara R DronamrajuDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Matthias LeungDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Andrew GruesenDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Ashish K SolankiDepartment of Medicine, Drug Discovery Building, Medical University of South Carolina, South Carolina, USA.ORCID 0000-0002-5043-1699
Stephen WalterhouseDepartment of Medicine, Drug Discovery Building, Medical University of South Carolina, South Carolina, USA.
Heidi RoehrichDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Grace SongDepartment of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA.
Rafael da Costa MonsantoDepartment of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA.
Sebahattin CureogluDepartment of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA.
René MartinFaculty of Chemistry, Technische Universität Dresden, Dresden, Germany.
Altaf A KondkarDepartment of Ophthalmology.
Frederik J van KuijkDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Sandra R MontezumaDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Hans-Joachim KnöelkerFaculty of Chemistry, Technische Universität Dresden, Dresden, Germany.
Robert B HufnagelOphthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
Glenn P LoboDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
University of Minnesota · USMedical University of South Carolina · USTechnische Universität Dresden · DEKing Saud University · SANational Institutes of Health · US

Funding

Physiological Role of the Vitamin A Transporter RBPR2 for VisionR01EY030889 · NEI · UNIVERSITY OF MINNESOTA · PI LOBO, GLENN P · 2020 to 2024
$1.8M
Physiological Role of the Zebrafish Retinol Receptor rbpr2 in VisionR21EY025034 · NEI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LOBO, GLENN P · 2015 to 2016
$436k
NEI NIH HHS R01 EY030889NEI NIH HHS R21 EY025034
6 · The paper itself

Abstract

backgroundRods and cones are photoreceptor neurons in the retina that are required for visual sensation in vertebrates, wherein the perception of vision is initiated when these neurons respond to photons in the light stimuli. The photoreceptor cell is structurally studied as outer segments (OS) and inner segments (IS) where proper protein sorting, localization, and compartmentalization are critical for phototransduction, visual function, and survival. In human retinal diseases, improper protein transport to the OS or mislocalization of proteins to the IS and other cellular compartments could lead to impaired visual responses and photoreceptor cell degeneration that ultimately cause loss of visual function.

resultsTherefore, studying and identifying mechanisms involved in facilitating and maintaining proper protein transport in photoreceptor cells would help our understanding of pathologies involving retinal cell degeneration in inherited retinal dystrophies, age-related macular degeneration, and Usher Syndrome.

conclusionsOur mini-review will discuss mechanisms of protein transport within photoreceptors and introduce a novel role for an unconventional motor protein, MYO1C, in actin-based motor transport of the visual chromophore Rhodopsin to the OS, in support of phototransduction and visual function.

Indexed as

Retinal DegenerationVision, OcularAnimalsHumansProtein TransportRetinaRetinal Cone Photoreceptor CellsRetinal Rod Photoreceptor CellsactinMotor proteinMyosin 1Couter segmentsphotoreceptorprotein localizationretinal degenerationRhodopsintraffickingvisual function

Identifiers

PMID35470760
PMCPMC9451523
OpenAlexW4224925621

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.