Evidence map›Paper›PMID 35470705›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation.

Kinga Kwiecinska, Wojciech Strojny, Miroslaw Bik-Multanowski, Michal Korostynski, Marcin Piechota, Walentyna Balwierz, Szymon Skoczen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kinga KwiecinskaDepartment of Oncology and Hematology, Institute of Pediatrics, 49573Jagiellonian University Medical College, Krakow, Poland.
Wojciech StrojnyDepartment of Oncology and Hematology, Institute of Pediatrics, 49573Jagiellonian University Medical College, Krakow, Poland.
Miroslaw Bik-MultanowskiDepartment of Medical Genetics, Institute of Pediatrics, 49573Jagiellonian University Medical College, Krakow, Poland.
Michal KorostynskiDepartment of Molecular Neuropharmacology Institute of Pharmacology of Polish Academy of Sciences, 414281Polish Academy of Sciences Cracow Branch, Krakow, Poland.
Marcin PiechotaDepartment of Molecular Neuropharmacology Institute of Pharmacology of Polish Academy of Sciences, 414281Polish Academy of Sciences Cracow Branch, Krakow, Poland.
Walentyna BalwierzDepartment of Oncology and Hematology, Institute of Pediatrics, 49573Jagiellonian University Medical College, Krakow, Poland.
Szymon SkoczenDepartment of Oncology and Hematology, Institute of Pediatrics, 49573Jagiellonian University Medical College, Krakow, Poland.ORCID https://orcid.org/0000-0001-6867-2717
Jagiellonian University · PLMaj Institute of Pharmacology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHematopoietic stem cell transplantation (HSCT) is the essential and often the only curative therapeutic option in high risk and relapsed pediatric acute lymphoblastic leukemia (ALL).

methodsThe objective of the study was to investigate whole-genome expression in children with high risk or relapsed ALL referred for HSCT. Gene expression was assessed in 18 children with ALL referred for HSCT (10 high risk, 8 relapsed; median age of 9.4 years) and in a control group of 38 obese children (median age of 14.1 years). Whole-genome expression was assessed in leukocytes using GeneChip® HumanGene 1.0 ST microarray.

resultsThe analysis of genomic profiles revealed a significantly lower expression of 21 genes with a defined function, involved in immunoglobulin production, lymphocyte function, or regulation of DNA processing in ALL patients referred for HSCT compared with the control group.

conclusionGenome expression of patients with ALL in remission referred to HSCT revealed deep immunosuppression of both B-cell and T-cell lineages, which may increase the probability of donor cell engraftment.

Indexed as

Hematopoietic Stem Cell TransplantationPediatric ObesityPrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentChildHumansacute lymphoblastic leukemiagenome expression profileHSCT

Identifiers

PMID35470705
PMCPMC9052811
OpenAlexW4224947650

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.