Evidence map›Paper›PMID 35470110›Full record

ArticleBiophysical journal2022

Left versus right: Exploring the effects of chiral threading intercalators using optical tweezers.

Adam A Jabak, Nicholas Bryden, Fredrik Westerlund, Per Lincoln, Micah J McCauley, Ioulia Rouzina, Mark C Williams, Thayaparan Paramanathan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Biophysics of cancer.Biophysical journal · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adam A JabakDepartment of Physics, Photonics and Optical Engineering, Bridgewater State University, Bridgewater, Massachusetts.
Nicholas BrydenDepartment of Physics, Photonics and Optical Engineering, Bridgewater State University, Bridgewater, Massachusetts.
Fredrik WesterlundDepartment of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Per LincolnDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Micah J McCauleyDepartment of Physics, Northeastern University, Boston, Massachusetts.
Ioulia RouzinaDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio.
Mark C WilliamsDepartment of Physics, Northeastern University, Boston, Massachusetts. Electronic address: mark@neu.edu.
Thayaparan ParamanathanDepartment of Physics, Photonics and Optical Engineering, Bridgewater State University, Bridgewater, Massachusetts. Electronic address: thaya@bridgew.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small-molecule DNA-binding drugs have shown promising results in clinical use against many types of cancer. Understanding the molecular mechanisms of DNA binding for such small molecules can be critical in advancing future drug designs. We have been exploring the interactions of ruthenium-based small molecules and their DNA-binding properties that are highly relevant in the development of novel metal-based drugs. Previously we have studied the effects of the right-handed binuclear ruthenium threading intercalator ΔΔ-[μ-bidppz(phen)

Indexed as

Intercalating AgentsRutheniumDNAOptical TweezersStereoisomerismDNAIntercalating AgentsRuthenium

Identifiers

PMID35470110
PMCPMC9617076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.