Evidence map›Paper›PMID 35470057›Full record

ArticleJournal of cardiac failure2022

Baseline Quality-of-Life of Caregivers of Patients With Heart Failure Prior to Advanced Therapies: Findings From the Sustaining Quality of Life of the Aged: Transplant or Mechanical Support (SUSTAIN-IT) Study.

M G Petty, T Wu, A C Andrei, A Baldridge, A Warzecha, A Kao, J Spertus, E Hsich, M A Dew, D Pham and 13 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cardiac failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Comprehensive Self-Management of Heart Failure.Journal of cardiovascular development and disease · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 14 institutions in 1 country.

M G PettyFrom the M Health Fairview, University of Minnesota Medical Center, Minneapolis, Minnesota. Electronic address: petty001@umn.edu.
T WuDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
A C AndreiDivision of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
A BaldridgeDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
A WarzechaDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
A KaoHeart Failure and Transplantation Cardiology, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri.
J SpertusCardiovascular Division, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri.
E HsichCardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio.
M A DewDepartment of Psychiatry, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania.
D PhamDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
C YancyDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
J HartupeeCardiovascular Division, Department of Medicine, Washington University, St. Louis, Missouri.
W CottsAdvocate Heart and Vascular Institute, Advocate Christ Medical Center, Oak Lawn, Illinois.
S V PamboukianDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
F PaganiDivision of Cardiovascular Surgery, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, Michigan.
B LampertDivision of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
M JohnsonDepartment of Cardiovascular Medicine, University of Wisconsin, Madison, Wisconsin.
M MurrayDepartment of Cardiovascular Surgery, University of Wisconsin Hospital and Clinics, Madison, Wisconsin.
K TekedaDepartment of Surgery, Columbia University Medical Center, New York, New York.
M YuzefpolskayaDivision of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York.
S SilvestryThoracic Transplant Programs, Florida Hospital Transplant institute, Orlando, Florida.
J K KirklinDivision of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
K L GradyDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Northwestern University · USColumbia University Irving Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Missouri–Kansas City · USAdvocate Christ Medical Center · USCleveland Clinic · USFairview Health Services · USMiami Transplant Institute · USThe Ohio State University · USUniversity of Michigan · USUniversity of Pittsburgh Medical Center · USUniversity of Wisconsin–Madison · USUW Health University Hospital · USWashington University in St. Louis · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Sustaining quality of life of the aged: Heart transplant or mechanical support?R01AG047416 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GRADY, KATHLEEN L · 2015 to 2019
$3.3M
NCATS NIH HHS UL1 TR001422NIA NIH HHS R01 AG047416
6 · The paper itself

Abstract

backgroundWe compared health-related quality of life (HRQOL), depressive symptoms, anxiety, and burden in caregivers of older patients with heart failure based on the intended therapy goal of the patient: awaiting heart transplantation (HT) with or without mechanical circulatory support (MCS) or prior to long-term MCS; and we identified factors associated with HRQOL.

methodsCaregivers (n = 281) recruited from 13 HT and MCS programs in the United States completed measures of HRQOL (EQ-5D-3L), depressive symptoms (PHQ-8), anxiety (STAI-state), and burden (Oberst Caregiving Burden Scale). Analyses included ANOVA, Kruskal-Wallis tests, χ

resultsThe majority of caregivers were female, white spouses with ≤ 2 comorbidities, median [Q1,Q3] age = 62 [57.8, 67.0] years. Caregivers (HT with MCS = 87, HT without MCS = 98, long-term MCS = 96) reported similarly high baseline HRQOL (EQ-5D-3L visual analog scale median score = 90; P = 0.67 for all groups) and low levels of depressive symptoms. STAI-state median scores were higher in the long-term MCS group vs the HT groups with and without MCS, (38 vs 32 vs 31; P < 0.001), respectively. Burden (task: time spent/difficulty) differed significantly among groups. Caregiver factors (number of comorbidities, diabetes and higher anxiety levels) were significantly associated with worse caregiver HRQOL, R

conclusionsRecognizing caregiver-specific factors, including comorbidities and anxiety, associated with the HRQOL of caregivers of these older patients with advanced HF may guide support strategies.

Indexed as

Heart FailureHeart TransplantationCaregiversComorbidityFemaleHumansMaleMiddle AgedQuality of LifeSurveys and QuestionnairesCaregiverhealth-related quality of life (HRQOL)heart failureheart transplantmechanical circulatory support

Identifiers

PMID35470057
PMCPMC10010287
OpenAlexW4224266189

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.