ArticleBrain, behavior, and immunity2022
Social cohesion and loneliness are associated with the antibody response to COVID-19 vaccination.
Article in Brain, behavior, and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- The relationship between psychological stress and SARS-CoV-2 nucleocapsid-antibody response following natural infection: longitudinal findings from the Aegis study.American journal of epidemiology · 2026Article
- Development and validation of the BASE-66 inventory for comprehensive academic stress measurement.PloS one · 2026Article
- The association between depressive symptoms and antibody response following SARS-CoV-2 vaccination among central North Carolina residents.PLOS mental health · 2025Article
- Recorded Loneliness and Adverse Outcomes in Older Acute Care Inpatients Receiving Psychiatric Assessment.International journal of geriatric psychiatry · 2025Article
- Lived experiences of farmworkers from five U. S. states during the COVID-19 pandemic.Frontiers in public health · 2025Article
- Impact of perceived neighborhood social cohesion on vaccination intentions in the post-pandemic era.Preventive medicine · 2024Article
- Effect of Distress, Anxiety, and Depressive Symptoms on SARS-CoV-2 mRNA BNT162b2 Vaccine Efficacy in Cancer Patients.Cancers · 2024Article
- Social Cohesion and COVID-19: Integrative Review.Interactive journal of medical research · 2024Review
- How does geographical diversity shape vaccine efficacy?Clinical and experimental vaccine research · 2024Review
- Examining the association of vaccine-related mindsets and post-vaccination antibody response, side effects, and affective outcomes.Brain, behavior, & immunity - health · 2024Article
- Social trust and COVID-19 mortality in the United States: lessons in planning for future pandemics using data from the general social survey.BMC public health · 2024Article
- From polarity to plurality: Perceptions of COVID-19 and policy measures in England and Scotland.Health expectations : an international journal of public participation in health care and health policy · 2024Article
- Article
- Psychology Meets Biology in COVID-19: What We Know and Why It Matters for Public Health.Policy insights from the behavioral and brain sciences · 2023Article
- Neighborhood social cohesion is associated with the willingness toward the booster dose of COVID-19 vaccines among the Chinese older population.Human vaccines & immunotherapeutics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundRecent research has suggested that psychosocial factors influence the antibody response to vaccine, including SARS-CoV-2 (COVID-19) vaccines. Here we investigated whether social cohesion and loneliness were predictive of antibody response to a single dose of a COVID-19 vaccine. We also tested if the association between social cohesion and antibody response was mediated by feelings of loneliness.
methodsParticipants (N = 676) COVID-19 antibody data were extracted from March 2021 wave of the Understanding Society COVID-19 study from the UK. Relevant socio-demographics, health and lifestyle, loneliness, social cohesion indices were also used in a series of hierarchical linear regression to test our main hypotheses.
resultsAfter controlling for covariates (e.g., age and chronic health conditions), lower social cohesion was associated with a lower antibody response. Further, the association between social cohesion and poorer antibody responses was mediated by loneliness; those reporting lower social cohesion also reported higher loneliness, which in turn was associated with lower antibody response.
conclusionThis study confirms that feelings of 'being in it together' relate to the strength of the antibody response to COVID-19 vaccination, emphasising the importance of the social cohesion agenda during the pandemic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.