Evidence map›Paper›PMID 35469617›Full record

ReviewImmunology and allergy clinics of North America2022

Anaphylaxis to Excipients in Current Clinical Practice: Evaluation and Management.

Maria A Bruusgaard-Mouritsen, Shuaib Nasser, Lene H Garvey, Matthew S Krantz, Cosby A Stone

Open access · greenAbstract readReview
In one paragraph

Review in Immunology and allergy clinics of North America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Inconsistent excipient listings in DailyMed: implications for drug safety.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Maria A Bruusgaard-MouritsenDepartment of Dermatology and Allergy, Allergy Clinic, Copenhagen University Hospital - Herlev and Gentofte, Hospitalsvej 8, 1st Floor, 2900 Hellerup, Copenhagen, Denmark.
Shuaib NasserDepartment of Allergy, Cambridge University Hospitals NHS Foundation Trust, Box 40, CB2 0QQ, Cambridge, UK.
Lene H GarveyDepartment of Dermatology and Allergy, Allergy Clinic, Copenhagen University Hospital - Herlev and Gentofte, Hospitalsvej 8, 1st Floor, 2900 Hellerup, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.
Matthew S KrantzDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Cosby A StoneDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: cosby.a.stone@vumc.org.
Vanderbilt University Medical Center · USCambridge University Hospitals NHS Foundation Trust · GBGentofte Hospital · DKUniversity of Copenhagen · DK

Funding

Clinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0M
Learning Health System Scholar Program at VanderbiltK12HS026395 · AHRQ · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROTHMAN, RUSSELL L., ROUMIE, CHRISTIANNE L. · 2018 to 2022
$2.7M
AHRQ HHS K12 HS026395NHLBI NIH HHS T32 HL087738
6 · The paper itself

Abstract

Excipients are the inactive ingredients in a drug or product that help to stabilize, preserve, or enhance the pharmacokinetics and bioavailability of the active ingredients. Excipient allergy is rare and hence often missed or misdiagnosed due to lack of awareness of the need to carefully review all drug ingredients. For the patient, excipient allergy can be frightening and potentially disruptive to health care delivery. This narrative review provides a clinically oriented, international, collaborative perspective on excipient allergy testing, management of future health care safety, limitations in our testing modalities, and barriers to optimal care.

Indexed as

AnaphylaxisExcipientsHumansPharmaceutical PreparationsExcipientsPharmaceutical PreparationsAllergyCarboxymethylcelluloseExcipientMannitolPolyethylene glycolPolysorbatePovidoneProtamine

Identifiers

PMID35469617
PMCPMC9907103
OpenAlexW4220737315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.