Evidence map›Paper›PMID 35469426›Full record

ArticleTissue engineering. Part C, Methods2022

Gelatin-Based Colloidal Versus Monolithic Gels to Regulate Macrophage-Mediated Inflammatory Response.

Zhumei Zhuang, Shengnan Sun, Kaiwen Chen, Yue Zhang, Xiaoman Han, Yang Zhang, Kai Sun, Fang Cheng, Lijun Zhang, Huanan Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part C, Methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zhumei ZhuangKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Shengnan SunKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Kaiwen ChenKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Yue ZhangKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Xiaoman HanKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Yang ZhangHealth Science Center, School of Stomatology, Shenzhen University, Shenzhen, China.
Kai SunKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Fang ChengKey State Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, China.
Lijun ZhangOptometric Center, Dalian Eye Hospital, Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian, China.
Huanan WangKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.ORCID 0000-0002-1228-2514
Dalian University of Technology · CNDalian University · CNThe Third People's Hospital of Dalian City · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unlike conventional monolithic hydrogels with covalent cross-linkage that are typically elastic, colloidal gels assembled by reversibly assembled particles as building blocks have shown fascinating viscoelastic properties. They follow a gel-sol transition upon yielding and recover to the initial state upon the release of the shear force (so-called shear-thinning and self-healing behavior); this makes them an ideal candidate as injectable and moldable biomaterials for tissue regeneration. The immune response provoked by the implantation of the colloidal gels with special viscoelastic and structural features is critical for the successful integration of the implants with the host tissues, which, however, remains little explored. Since macrophages are known as the primary immune cells in determining the inflammatory response against the implants, we herein investigated

Indexed as

GelatinHydrogelsBiocompatible MaterialsMacrophagesMethacrylatesBiocompatible MaterialsGelatinHydrogelsMethacrylatescolloidal gelgelatininflammatory responsemacrophage polarizationsubcutaneous implantationviscoelasticity

Identifiers

PMID35469426
PMCPMC9347396
OpenAlexW4224437561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.