ArticleHIV/AIDS (Auckland, N.Z.)2022
Incidence and Predictors of Opportunistic Infections Among Adult HIV Infected Patients on Anti-Retroviral Therapy at Dessie Comprehensive Specialized Hospital, Ethiopia: A Retrospective Follow-Up Study.
Article in HIV/AIDS (Auckland, N.Z.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Pooled it
- Opportunistic infections among schoolchildren who were on antiretroviral therapy in Ethiopia: a systematic review and meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Incidence, survival, and risk factors for first-line antiretroviral therapy failure among adults on ART follow-up in health facilities in Southwest Shoa, Oromia, Ethiopia, 2023: a retrospective cohort study.BMC infectious diseases · 2026Article
- Predictors of opportunistic infections among people living with HIV: a prospective cohort study from a tertiary care setting in India.Scientific reports · 2026Article
- Incidence and Predictors of Opportunistic Infection Among People Living With HIV in Ethiopia: A Systematic Review and Meta-Analysis.AIDS research and treatment · 2026Review
- Outcomes and risk factors in HIV-positive patients with sepsis: a retrospective study.European journal of medical research · 2025Article
- Global prevalence of advanced HIV disease in healthcare settings: a rapid review.Journal of the International AIDS Society · 2025Review
- Prevalence of Opportunistic Infections and Determinants Among HIV-Positive Patients in Ethiopia: A Systematic Review and Meta-Analysis.Health science reports · 2025Article
- Machine learning-based prediction of mortality risk in AIDS patients with comorbid common AIDS-related diseases or symptoms.Frontiers in public health · 2025Article
- The Epidemiology and Determinants of Opportunistic Intestinal Parasites Among HIV-Positive Patients Attending Care and Treatment Centers in Northcentral Ethiopia.Journal of parasitology research · 2025Article
- Developing HIV indicators for clinical care quality assessment: relevance and practicality evaluated by healthcare practitioners in South Africa and Democratic Republic of Congo.BMJ open quality · 2024Observational
- Article
- Active tuberculosis incidence among treatment failure experienced patients in North Wollow Zone: A multicenter historical cohort.Health science reports · 2024Article
- Article
- The effect of the Universal Test and Treat policy uptake on CD4 count testing and incidence of opportunistic infections among people living with HIV infection in Cameroon: a retrospective analysis of routine data.Dialogues in health · 2023Article
- The spectrum of opportunistic infections and malignancies among women on antiretroviral therapy in Ethiopia.Emerging microbes & infections · 2023Article
- Cryptococcal meningitis among perinatally HIV-infected adolescents: Case series on presentation and management challenges.Clinical case reports · 2023Article
- Quality of Life and Associated Factors of HIV Patients Under Treatment with First Line Regimens in Public Hospitals in Amhara Region, North-West Ethiopia.Patient preference and adherence · 2023Article
- Prevalence and determinants of opportunistic infections among HIV-infected adults receiving antiretroviral therapy in Ethiopia: A systematic review and meta-analysis.Frontiers in medicine · 2023Review
- A Hydrodynamic Approach to the Study of HIV Virus-Like Particle (VLP) Tangential Flow Filtration.Membranes · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Opportunistic infections are the major causes for morbidity and mortality due to HIV infections. Despite advances in HIV diagnosis and management, the incidence of opportunistic infections remains high. This study aimed to assess the incidence and predictors of opportunistic infections among persons living with HIV/AIDS in Ethiopia. Methods: A retrospective follow-up study was conducted on 354 samples of adults living with HIV on antiretroviral therapy at Dessie Comprehensive Specialized Hospital. Simple random sampling technique was used to select study participants. The data collection format was taken from national antiretroviral intake and follow-up forms. Epi-data Version 4.6.1 and STATA Version 16 software were used for data entry and data analysis respectively. The Cox-proportional hazards regression model was fitted. Kaplan-Meier survival curve was used to estimate opportunistic infections-free survival time. Both bi-variable and multivariable Cox-proportional hazard regression analysis were done to identify predictors of opportunistic infections. Results: Of the total 354 peoples living with HIV, 114 (32.2%) developed OI, with an incidence rate of 13.5 per 100 person-year (95% CI: 10.8-15.6). Advanced World Health Organization clinical disease stage (IV) (AHR: 2.1 (95% CI: 1.16, 3.8)), being bedridden (AHR: 1.66 (95% CI: 1.04, 2.65)), poor adherence (AHR: 1.7 (95% CI: 1.1-2.63), and low CD4 count (AHR: 1.92 95% CI: 1.14-3.22) were significant predictors of OIs. Conclusion: Opportunistic infection among HIV/AIDS continues to be a significant public health concern in Ethiopian health care setting. Our results indicate that the incidence of OI is high. Besides, Stage IV HIV status, being bedridden, low CD4 count and poor adherence independently predicts an increased incidence/decreased survival time of OIs among PLWHIV. Early care-seeking and initiation of HAART and continuous follow-up of patients to take their drug timely are essential to curb the incidence of opportunistic infections and improve overall health. Further research on this area is highly recommended.
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