Evidence map›Paper›PMID 35469231›Full record

ArticleJournal of healthcare engineering2022

miR-139-5p Suppresses Proliferation and Angiogenesis of Intracranial Aneurysm via FGB.

Tao Jin, Gong Chen, Qingzhu An, Xuanfeng Qin, Yuanyuan Hu, Yan Yan, Jia Hu, Bing Zhou, Bing Leng

Open access · hybridAbstract read
In one paragraph

Article in Journal of healthcare engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Epigenetic mechanisms in aneurysm formation, growth, and rupture: A systematic review.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tao JinDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Gong ChenDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Qingzhu AnDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Xuanfeng QinDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Yuanyuan HuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Yan YanDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Jia HuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Bing ZhouDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Bing LengDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-3155-7819
Fudan University · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracranial aneurysm (IA) is a common cerebrovascular disease. Understanding the mechanism regulating the progression of IA could help to develop novel therapeutic methods for this disease. In this study, we confirmed FGB is one of the targets of miR-139-5p. Moreover, miR-139-5p expression in intracranial aneurysm specimens was suppressed compared with normal tissues. However, we found that FGB in intracranial aneurysm samples was remarkedly enhanced compared to normal tissues. Moreover, we found miR-139-5p overexpression and FGB silencing inhibit HBMEC proliferation and tube formation and suppressed

Indexed as

Intracranial AneurysmMicroRNAsCell ProliferationFibrinogenGene Expression Regulation, NeoplasticHumansFGB protein, humanFibrinogenMicroRNAsMIRN139 microRNA, human

Identifiers

PMID35469231
PMCPMC9034926
OpenAlexW4224083728

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.