Evidence map›Paper›PMID 35468973›Full record

ArticleNPJ vaccines2022

A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2.

Philipp A Ilinykh, Sivakumar Periasamy, Kai Huang, Natalia A Kuzmina, Palaniappan Ramanathan, Michelle N Meyer, Chad E Mire, Ivan V Kuzmin, Preeti Bharaj, Jessica R Endsley and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Philipp A IlinykhDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Sivakumar PeriasamyDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.ORCID http://orcid.org/0000-0002-7038-5140
Kai HuangDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.ORCID http://orcid.org/0000-0002-3373-5594
Natalia A KuzminaDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.ORCID http://orcid.org/0000-0001-6650-9369
Palaniappan RamanathanDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Michelle N MeyerDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Chad E MireDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.ORCID http://orcid.org/0000-0001-7596-1808
Ivan V KuzminDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Preeti BharajDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Jessica R EndsleyDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Maria ChikinaDepartment of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Stuart C SealfonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Steven G WidenDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Mark A EndsleyDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Alexander BukreyevDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA. alexander.bukreyev@utmb.edu.ORCID http://orcid.org/0000-0002-0342-4824
Galveston College · USThe University of Texas Medical Branch at Galveston · USIcahn School of Medicine at Mount Sinai · USUniversity of Pittsburgh · US

Funding

University of Texas Medical Branch at Galveston | Institute for Translational Sciences, University of Texas Medical Branch (Institute for Translational Sciences at UTMB) N/A
6 · The paper itself

Abstract

Respiratory tract vaccination has an advantage of needle-free delivery and induction of mucosal immune response in the portal of SARS-CoV-2 entry. We utilized human parainfluenza virus type 3 vector to generate constructs expressing the full spike (S) protein of SARS-CoV-2, its S1 subunit, or the receptor-binding domain, and tested them in hamsters as single-dose intranasal vaccines. The construct bearing full-length S induced high titers of neutralizing antibodies specific to S protein domains critical to the protein functions. Robust memory T cell responses in the lungs were also induced, which represent an additional barrier to infection and should be less sensitive than the antibody responses to mutations present in SARS-CoV-2 variants. Following SARS-CoV-2 challenge, animals were protected from the disease and detectable viral replication. Vaccination prevented induction of gene pathways associated with inflammation. These results indicate advantages of respiratory vaccination against COVID-19 and inform the design of mucosal SARS-CoV-2 vaccines.

Identifiers

PMID35468973
PMCPMC9038905
OpenAlexW4224941614

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.