Evidence map›Paper›PMID 35468648›Full record

ArticlePlanta medica2022

Kratom (Mitragyna speciosa) Validation: Quantitative Analysis of Indole and Oxindole Alkaloids Reveals Chemotypes of Plants and Products.

Preston K Manwill, Laura Flores-Bocanegra, Manead Khin, Huzefa A Raja, Nadja B Cech, Nicholas H Oberlies, Daniel A Todd

Open access · hybridAbstract read
In one paragraph

Article in Planta medica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Evaluating the drug interactions in kratom usage: clinical application.Expert opinion on drug metabolism & toxicology · 2025
    Review
  7. Article
  8. Journal of Taibah University Medical Sciences · 2024
    Review
  9. Article
  10. Review
  11. Review
  12. Translating Kratom-Drug Interactions: From Bedside to Bench and Back.Drug metabolism and disposition: the biological fate of chemicals · 2023
    Review
  13. Article
  14. Standardization of açaí extracts forJournal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems · 2023
    Article
  15. Article
  16. Article
  17. Interpol Review of Drug Analysis 2019-2022.Forensic science international. Synergy · 2023
    Review
  18. Acute, Sublethal, and Developmental Toxicity of Kratom (International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Preston K ManwillDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
Laura Flores-BocanegraDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
Manead KhinDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
Huzefa A RajaDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
Nadja B CechDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.ORCID 0000-0001-6773-746X
Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.ORCID 0000-0002-0354-8464
Daniel A ToddDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
University of North Carolina at Greensboro · US

Funding

Pharmacology CoreU54AT008909 · NCCIH · WASHINGTON STATE UNIVERSITY · PI PAINE, MARY F · 2015 to 2024
$22.4M
NCCIH NIH HHS U54 AT008909U54 AT008909 National Center for Complementary and Integrative Health
6 · The paper itself

Abstract

Many consumers are turning to kratom (

Indexed as

MitragynaSecologanin Tryptamine AlkaloidsChromatography, High Pressure LiquidIndole AlkaloidsOxindolesPlant LeavesIndole AlkaloidsOxindolesSecologanin Tryptamine Alkaloids

Identifiers

PMID35468648
PMCPMC9343938
OpenAlexW4224443409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.