Evidence map›Paper›PMID 35468416›Full record

ArticleBioorganic chemistry2022

Organomediated cleavage of benzoyl group enables an efficient synthesis of 1-(6-nitropyridin-2-yl)thiourea and its application for developing

Junfeng Wang, Kazue Takahashi, Timothy M Shoup, Lichong Gong, Yingbo Li, Georges El Fakhri, Zhaoda Zhang, Anna-Liisa Brownell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junfeng WangGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States. Electronic address: jwang83@mgh.harvard.edu.
Kazue TakahashiGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States.
Timothy M ShoupGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States.
Lichong GongMartinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States.
Yingbo LiState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Georges El FakhriGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States.
Zhaoda ZhangMartinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States. Electronic address: ZZHANG9@mgh.harvard.edu.
Anna-Liisa BrownellGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States. Electronic address: abrownell@mgh.harvard.edu.

Funding

Positive Allosteric Modulators as PET Imaging Ligans for mGluR4R01NS100164 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA, ZHANG, ZHAODA · 2016 to 2020
$3.7M
Development of PET imaging probes for metabolic glutamate receptor 3 (mGLuR3)K25AG061282 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, JUNFENG · 2019 to 2023
$754k
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
NIA NIH HHS K25 AG061282NIH HHS S10 OD025234NINDS NIH HHS R01 NS100164
6 · The paper itself

Abstract

A novel organomediated cleavage of benzoyl group using ethane-1,2-diamine and acetic acid under neutral condition enables an efficient synthesis of 1-(6-nitropyridin-2-yl)thiourea, which previously has been challenging to prepare by conventional methods. The successful synthesis of 1-(6-nitropyridin-2-yl)thiourea as a synthon permits development of a variety of

Indexed as

BrainThioureaAnimalsLigandsPositron-Emission TomographyRatsLigandsThioureaCleavage reactionHeterocyclesOrganomediated reactionortho-FluoropyridinesPositron emission tomography

Identifiers

PMID35468416
PMCPMC9189786

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.