Evidence map›Paper›PMID 35468245›Full record

ArticleMagnetic resonance in medicine2022

Assessing the effect of anesthetic gas mixtures on hyperpolarized

Richard Healicon, Catriona H E Rooney, Vicky Ball, Ayaka Shinozaki, Jack J Miller, Sean Smart, Daniel Radford-Smith, Daniel Anthony, Damian J Tyler, James T Grist

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Metabolic Imaging of Hyperpolarized [1-International journal of molecular sciences · 2025
    Article
  4. Article
  5. Investigating the origin of theNMR in biomedicine · 2024
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Richard HealiconDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom.
Catriona H E RooneyDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-4973-3347
Vicky BallDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom.
Ayaka ShinozakiDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom.
Jack J MillerDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-6258-1299
Sean SmartNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Daniel Radford-SmithDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.
Daniel AnthonyDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.
Damian J TylerDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom.
James T GristDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-7223-4031
University of Oxford · GBAarhus University Hospital · DKClarendon College · USJohn Radcliffe Hospital · GB

Funding

British Heart Foundation FS/10/002/28078British Heart Foundation FS/14/17/30634British Heart Foundation FS/19/18/34252Medical Research Council BRT00030 AV20Medical Research Council EP/L016052/1Medical Research Council G0601490
6 · The paper itself

Abstract

purposeTo determine the effect of altering anesthetic oxygen protocols on measurements of cerebral perfusion and metabolism in the rodent brain.

methodsSeven rats were anesthetized and underwent serial MRI scans with hyperpolarized [1-

resultsThere was a significant increase in bicarbonate:total

conclusionsThese results demonstrate that the detection and quantification of cerebral metabolism and perfusion is dependent on the oxygen protocol used in the anesthetized rodent brain.

Indexed as

Anesthetics, InhalationBicarbonatesAnimalsBrainCarbon IsotopesMagnetic Resonance ImagingOxygenPyruvic AcidRatsAnesthetics, InhalationBicarbonatesCarbon IsotopesOxygenPyruvic AcidbrainhyperpolarizedmetabolismMRI

Identifiers

PMID35468245
PMCPMC9325476
OpenAlexW4224321018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.