ArticlePloS one2022
Melanin pigment of Streptomyces puniceus RHPR9 exhibits antibacterial, antioxidant and anticancer activities.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Optimized melanin production from marine-associated Bacillus sp. EGY7 as a sustainable precursor of carbon dots for biomedical applications.Bioresources and bioprocessing · 2026Article
- Using physical elicitors to enhance pigment production inBiotechnologia · 2026Article
- "Functional profiling and computational optimization of production of extracellular melanin from endophytic Pseudomonas plecoglossicida SSSK-2 isolated from Neolamarckia cadamba".International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Pharmaceutical and Biotechnological Perspectives Regarding Melanin Pigment From Streptomyces spp.Cureus · 2025Article
- Streptomyces zaomycetitus strain GH90: a source of violet pigment with metabolic profiling and potential application in textile: in vitro supported by in silico studies and molecular docking.BMC microbiology · 2025Article
- Insights into the antibacterial, antioxidant, and fabric colorant applications by pigment-producing actinomycetes from Sof-Umer cave rocks and sediments.BMC microbiology · 2025Article
- Metal Ion Supplementation to Boost Melanin Production byInternational journal of molecular sciences · 2025Article
- Actinomycetes: A Source of Anticancer Metabolites.Current medicinal chemistry · 2025Review
- Antimicrobial Activity of Melanin Isolated from Wine Waste.Indian journal of microbiology · 2024Article
- Pigments from pathogenic bacteria: a comprehensive update on recent advances.World journal of microbiology & biotechnology · 2024Review
- Unveiling the Bioprospecting Efficacy and Textile Dyeing of a Novel Endophytic Mycobial Red Pigment.Indian journal of microbiology · 2024Article
- Streptomycetes as Microbial Cell Factories for the Biotechnological Production of Melanin.International journal of molecular sciences · 2024Review
- Bioproduction and optimization of newly characterized melanin pigment from Streptomyces djakartensis NSS-3 with its anticancer, antimicrobial, and radioprotective properties.Microbial cell factories · 2024Article
- Melanin Synthesized by the EndophyticCurrent topics in medicinal chemistry · 2024Article
- A comparative study using response surface methodology and artificial neural network towards optimized production of melanin by Aureobasidium pullulans AKW.Scientific reports · 2023Article
- Recent Applications of Melanin-like Nanoparticles as Antioxidant Agents.Antioxidants (Basel, Switzerland) · 2023Review
- Antagonistic Potentiality of Actinomycete-Derived Extract with Anti-Biofilm, Antioxidant, and Cytotoxic Capabilities as a Natural Combating Strategy for Multidrug-Resistant ESKAPE Pathogens.Journal of microbiology and biotechnology · 2023Article
- Anti-ultraviolet, antibacterial, and biofilm eradication activities againstFrontiers in microbiology · 2023Article
- Insight into Recent Progress and Perspectives in Improvement of Antioxidant Machinery upon PGPR Augmentation in Plants under Drought Stress: A Review.Antioxidants (Basel, Switzerland) · 2022Review
- Article
Corrections and comments
- Retraction · 2022-08-03Concerns/Issues about Authorship/Affiliation · Conflict of Interest · Compromised Peer Review ·
- Retracted
Authors and funding
11 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study reveals the production of dark, extracellular melanin pigment (386 mg/L) on peptone yeast extract iron agar medium by Streptomyces puniceus RHPR9 using the gravimetric method. UV-Visible, Fourier Transform Infrared (FTIR), and Nuclear Magnetic Resonance (1H) (NMR) spectroscopy confirmed the presence of melanin. Extracted melanin showed antibacterial activity against human pathogens such as Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli except for Klebsiella pneumoniae. A potent free radical scavenging activity was observed at 100 μg/mL of melanin by the DPPH method with a concentration of 89.01±0.05% compared with ascorbic acid 96.16±0.01%. Antitumor activity of melanin was evaluated by MTT assay against HEK 293, HeLa, and SK-MEL-28 cell lines with IC50 values of 64.11±0.00, 14.43±0.02, and 13.31±0.01 μg/mL respectively. Melanin showed maximum anti-inflammatory activity with human red blood cells (hRBC) (78.63 ± 0.01%) and minimum hemolysis of 21.37±0.2%. The wound healing potential of the pigment was confirmed on HeLa cells, cell migration was calculated, and it was observed that cell migration efficiency decreased with an increase in the concentration of melanin. To our knowledge, this is the first evidence of melanin produced from S. puniceus RHPR9 that exhibited profound scavenging, anti-inflammatory and cytotoxic activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.