ArticlePLoS genetics2022
MiR172-APETALA2-like genes integrate vernalization and plant age to control flowering time in wheat.
Article in PLoS genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 26 papers.
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26 citing papers in PubMed, 47 citations in OpenAlex.
- Post-Translational Control of TaFT1 by WAPO1 Ubiquitination Shapes Spike Architecture and Yield in Wheat.Plant biotechnology journal · 2026Article
- RNA regulation in plants.Science China. Life sciences · 2026Review
- Genome-wide identification and characterization of the RNAi gene families in Brassica rapa L. highlighting their regulatory components and underlying functions involving crop improvement.BMC genomic data · 2026Article
- Molecular-physiological model integration revolutionizes cereal flowering prediction.The New phytologist · 2026Article
- MicroRNA156 and its targeted SPL genes interact with the photoperiod, vernalization, and gibberellin pathways to regulate wheat heading time.The Plant journal : for cell and molecular biology · 2026Article
- Article
- Whole-transcriptome dynamics reveal distinct regulatory networks during sugar beet vernalization.Frontiers in plant science · 2026Article
- Genetic control of seasonal meristem arrest in trees.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring the multifaceted dynamics of flowering time regulation in field crops: Insight and intervention approaches.The plant genome · 2025Review
- Low-Temperature and Light Pretreatment Interactively Promote Rapid Flowering, Early Ripening, and Yield Accumulation of Winter Wheat.International journal of molecular sciences · 2025Article
- Effects of five allelic variants of the wheat vernalization geneMolecular breeding : new strategies in plant improvement · 2025Article
- Molecular genetic regulation of the vegetative-generative transition in wheat from an environmental perspective.Annals of botany · 2025Review
- Historic rewiring of grass flowering time pathways and implications for crop improvement under climate change.The New phytologist · 2025Review
- Editorial Note: MiR172-APETALA2-like genes integrate vernalization and plant age to control flowering time in wheat.PLoS genetics · 2025Article
- Transcriptome Profiling Reveals Key Regulatory Networks for Age-Dependent Vernalization in Welsh Onion (International journal of molecular sciences · 2024Article
- Wheat improvement through advances in single nucleotide polymorphism (SNP) detection and genotyping with a special emphasis on rust resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Accumulation of mutations in theMolecular breeding : new strategies in plant improvement · 2024Article
- A 49-bp deletion ofHorticulture research · 2024Article
- Overexpression of lily MicroRNA156-resistantFrontiers in plant science · 2024Article
- Identification of a novel SNP in the miR172 binding site of Q homoeolog AP2L-D5 is associated with spike compactness and agronomic traits in wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
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5 authors at 1 institution in 1 country.
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Abstract
Plants possess regulatory mechanisms that allow them to flower under conditions that maximize reproductive success. Selection of natural variants affecting those mechanisms has been critical in agriculture to modulate the flowering response of crops to specific environments and to increase yield. In the temperate cereals, wheat and barley, the photoperiod and vernalization pathways explain most of the natural variation in flowering time. However, other pathways also participate in fine-tuning the flowering response. In this work, we integrate the conserved microRNA miR172 and its targets APETALA2-like (AP2L) genes into the temperate grass flowering network involving VERNALIZATION 1 (VRN1), VRN2 and FLOWERING LOCUS T 1 (FT1 = VRN3) genes. Using mutants, transgenics and different growing conditions, we show that miR172 promotes flowering in wheat, while its target genes AP2L1 (TaTOE1) and AP2L5 (Q) act as flowering repressors. Moreover, we reveal that the miR172-AP2L pathway regulates FT1 expression in the leaves, and that this regulation is independent of VRN2 and VRN1. In addition, we show that the miR172-AP2L module and flowering are both controlled by plant age through miR156 in spring cultivars. However, in winter cultivars, flowering and the regulation of AP2L1 expression are decoupled from miR156 downregulation with age, and induction of VRN1 by vernalization is required to repress AP2L1 in the leaves and promote flowering. Interestingly, the levels of miR172 and both AP2L genes modulate the flowering response to different vernalization treatments in winter cultivars. In summary, our results show that conserved and grass specific gene networks interact to modulate the flowering response, and that natural or induced mutations in AP2L genes are useful tools for fine-tuning wheat flowering time in a changing environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.