Evidence map›Paper›PMID 35468028›Full record

ArticlePharmaceutical development and technology2022

Cholecalciferol complexation with hydroxypropyl-β-cyclodextrin (HPBCD) and its molecular dynamics simulation.

Fang Wang, Wenbo Yu, Carmen Popescu, Ahmed Ashour Ibrahim, Dongyue Yu, Ryan Pearson, Alexander D MacKerell, Stephen W Hoag

Open access · greenAbstract read
In one paragraph

Article in Pharmaceutical development and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Complexes of Fat-Soluble Vitamins with Cyclodextrins.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Highly selective whole-cell 25-hydroxyvitamin DMicrobial cell factories · 2024
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fang WangDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Wenbo YuDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Carmen PopescuRoquette America Inc., Geneva, IL, USA.
Ahmed Ashour IbrahimDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Dongyue YuDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Ryan PearsonDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Alexander D MacKerellDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Stephen W HoagDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
University of Maryland, Baltimore · US

Funding

Macromolecular Conformational HeterogeneityR35GM131710 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI ALEXANDER D MACKERELL · 2019 to 2026
$6.2M
NIGMS NIH HHS R35 GM131710
6 · The paper itself

Abstract

The focus of the current study is to investigate cholecalciferol (vitamin D3) solubilization by hydroxypropyl-β-cyclodextrin (HPBCD) complexation through experimental and computational studies. Phase solubility diagram of vitamin D3 (completely insoluble in water) has an A

Indexed as

beta-CyclodextrinsMolecular Dynamics Simulation2-Hydroxypropyl-beta-cyclodextrinCalorimetry, Differential ScanningCholecalciferolSolubilitySpectroscopy, Fourier Transform InfraredX-Ray Diffraction2-Hydroxypropyl-beta-cyclodextrinbeta-CyclodextrinsCholecalciferolCholecalciferol (vitamin D3)complexhydroxypropyl-β-cyclodextrin (HPBCD)molecular dynamic (MD) simulationsmolecular modeling

Identifiers

PMID35468028
PMCPMC9233054
OpenAlexW4224317466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.