ArticleProceedings of the National Academy of Sciences of the United States of America2022
Bacterial lipopolysaccharide induces settlement and metamorphosis in a marine larva.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- In situ enhancement of coral larval settlement using acoustic enrichment, engineered habitats and living materials.Communications biology · 2026Article
- Bacterial Cytochrome C Orchestrates Larval Metamorphosis Through Bioelectrical Control of Extracellular Vesicles Biogenesis.Journal of extracellular vesicles · 2026Article
- Functional Microbiomes at the Interface: Mediators in Marine Biofouling and Larval Settlement.International journal of molecular sciences · 2026Review
- Strain-specific surface polysaccharides mediate bacterial induction of metamorphosis in the coralPNAS nexus · 2026Article
- Anthropogenic Disruption Versus Natural Restoration: Enterobacter cloacae-Driven Barnacle Larval Settlement and Its Mitigation via Natural Bacteriophages.Microbial biotechnology · 2026Article
- Directed assembly of biofilm communities for marine biofouling prevention.Applied and environmental microbiology · 2025Article
- Microbial living materials promote coral larval settlement.PNAS nexus · 2025Article
- The biofouling tubeworm Hydroides elegans.Nature methods · 2025Article
- An ancient immune pathway enables animal metamorphosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The role of microbiota in kelp gametophyte development and resilience to thermal stress.Journal of phycology · 2025Article
- Light and dark biofilm adaptation impacts larval settlement in diverse coral species.Environmental microbiome · 2025Article
- Chemical signaling in biofilm-mediated biofouling.Nature chemical biology · 2024Review
- Marine Delivery Vehicles: Molecular Components and Applications of Bacterial Extracellular Vesicles.Marine drugs · 2024Review
- Outer membrane vesicles from commensal microbes contribute to the sponge Tedania sp. development by regulating the expression level of apoptosis-inducing factor (AIF).Communications biology · 2024Article
- Bacterial envelope polysaccharide cues settlement and metamorphosis in the biofouling tubeworm Hydroides elegans.Communications biology · 2024Article
- Bacterial c-di-GMP triggers metamorphosis of mussel larvae through a STING receptor.NPJ biofilms and microbiomes · 2024Article
- Bacterial c-di-GMP signaling gene affects mussel larval metamorphosis through outer membrane vesicles and lipopolysaccharides.NPJ biofilms and microbiomes · 2024Article
- Inter-kingdom communication and the sympoietic way of life.Frontiers in cell and developmental biology · 2024Article
- Crude Oil and Its Burnt Residues Induce Metamorphosis in Marine Invertebrates.Environmental science & technology · 2023Article
- Future research directions of the model marine tubeworm Hydroides elegans and synthesis of developmental staging of the complete life cycle.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How larvae of the many phyla of marine invertebrates find places appropriate for settlement, metamorphosis, growth, and reproduction is an enduring question in marine science. Biofilm-induced metamorphosis has been observed in marine invertebrate larvae from nearly every major marine phylum. Despite the widespread nature of this phenomenon, the mechanism of induction remains poorly understood. The serpulid polychaete Hydroides elegans is a well established model for investigating bacteria-induced larval development. A broad range of biofilm bacterial species elicit larval metamorphosis in H. elegans via at least two mechanisms, including outer membrane vesicles (OMVs) and complexes of phage-tail bacteriocins. We investigated the interaction between larvae of H. elegans and the inductive bacterium Cellulophaga lytica, which produces an abundance of OMVs but not phage-tail bacteriocins. We asked whether the OMVs of C. lytica induce larval settlement due to cell membrane components or through delivery of specific cargo. Employing a biochemical structure–function approach with a strong ecological focus, the cells and OMVs produced by C. lytica were interrogated to determine the class of the inductive compounds. Here, we report that larvae of H. elegans are induced to metamorphose by lipopolysaccharide produced by C. lytica. The widespread prevalence of lipopolysaccharide and its associated taxonomic and structural variability suggest it may be a broadly employed cue for bacterially induced larval settlement of marine invertebrates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.