Evidence map›Paper›PMID 35467708›Full record

ArticleEuropean heart journal2022

Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study.

Christina M Eckhardt, Pallavi P Balte, Robert Graham Barr, Alain G Bertoni, Surya P Bhatt, Michael Cuttica, Patricia A Cassano, Paolo Chaves, David Couper, David R Jacobs and 15 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Association of preserved ratio impaired spirometry with mortality: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Is There any Correlation Between Pulmonary and Coronary Involvement in Diabetic Patients?International journal of endocrinology and metabolism · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Pulmonary hypertension associated with left heart disease.The European respiratory journal · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 15 institutions in 1 country.

Christina M EckhardtDepartment of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, Presbyterian Hospital 9th Floor, Suite 105, New York, NY 10032, USA.ORCID 0000-0002-3249-926X
Pallavi P BalteDepartment of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, Presbyterian Hospital 9th Floor, Suite 105, New York, NY 10032, USA.
Robert Graham BarrDepartment of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, Presbyterian Hospital 9th Floor, Suite 105, New York, NY 10032, USA.
Alain G BertoniDivision of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-7503-6273
Surya P BhattDivision of Pulmonary, University of Alabama at Birmingham, Allergy and Critical Care Medicine, Birmingham, AL, USA.
Michael CutticaDepartment of Medicine, Northwestern University, Chicago, IL, USA.
Patricia A CassanoDivision of Nutritional Sciences, Cornell University, College of Human Ecology, Cornell, NY, USA.ORCID 0000-0003-4827-5073
Paolo ChavesDepartment of Health and Society, Florida International University, Miami, FL, USA.ORCID 0000-0001-8013-7928
David CouperDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-4313-9235
David R JacobsDivision of Epidemiology and Community Health, University of Minnesota, School of Public Health, Minneapolis, MN, USA.ORCID 0000-0002-7232-0543
Ravi KalhanDepartment of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-2443-0876
Richard KronmalDepartment of Statistics, University of Washington, School of Public Health, Seattle, WA, USA.
Leslie LangeDepartment of Medicine, University of Colorado, Denver, CO, USA.
Laura LoehrDepartment of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Stephanie J LondonNational Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.ORCID 0000-0003-4911-5290
George T O'ConnorDepartment of Medicine, Boston University, Boston, MA, USA.
Wayne RosamondDepartment of Medicine, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0001-5271-074X
Jason SandersDivision of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Joseph E SchwartzNational Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.ORCID 0000-0002-8944-3566
Amil ShahDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-1056-4451
Sanjiv J ShahDepartment of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-5655-8201
Lewis SmithDepartment of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-4728-1562
Wendy WhiteUndergraduate Training and Education Center, Tougaloo College, Jackson Heart Study, Jackson, MS, USA.
Sachin YendeDepartment of Critical Care Medicine, Veterans Affairs Pittsburgh Healthcare System and University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-6596-8034
Elizabeth C OelsnerDepartment of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, Presbyterian Hospital 9th Floor, Suite 105, New York, NY 10032, USA.ORCID 0000-0002-7481-9671
Northwestern University · USPresbyterian Hospital · USUniversity of North Carolina at Chapel Hill · USBrigham and Women's Hospital · USNational Institutes of Health · USBoston University · USCornell University · USFlorida International University · USTougaloo College · USUniversity of Alabama at Birmingham · USUniversity of Colorado Denver · USUniversity of Minnesota · USUniversity of Pittsburgh · USUniversity of Washington · USWake Forest University · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
The Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2M
HeartShare DeCODE-HF: Data translation center to Combine Omics, Deep phenotyping, and Electronic health records for Heart Failure subtypes and treatment targetsU54HL160273 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Abel N. Kho, Yuan Luo · 2021 to 2026
$19.0M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Transitions from Impaired Respiratory Health to Lung DiseaseR01HL122477 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RAVI KALHAN · 2014 to 2026
$17.3M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
STRONG HEART STUDY (SHS): OUHSC COORDINATING CENTER - TASK AREA B (B.1 AND B.3)75N92019D00027 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZHANG, YING · 2019 to 2025
$15.5M
CARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
STRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9M
NRSA Training CoreTL1TR001875 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPANN, MARISA N, TAYLOR, JACQUELYN Y · 2016 to 2025
$8.9M
NCATS NIH HHS TL1 TR001875NCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1 TR001873NHLBI NIH HHS 75N92019D00027NHLBI NIH HHS 75N92019D00028NHLBI NIH HHS 75N92019D00029NHLBI NIH HHS 75N92019D00030NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K23 HL130627NHLBI NIH HHS K24 HL152008NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL107577NHLBI NIH HHS R01 HL109282NHLBI NIH HHS R01 HL109284NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R01 HL109315NHLBI NIH HHS R01 HL109319NHLBI NIH HHS R01 HL122477NHLBI NIH HHS R01 HL140731NHLBI NIH HHS R01 HL149423NHLBI NIH HHS R21 HL121457NHLBI NIH HHS R21 HL129924NHLBI NIH HHS RC1 HL100543NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U54 HL160273NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG028050NIDDK NIH HHS R01 DK089174NIMHD NIH HHS HHSN268201800013ININR NIH HHS R01 NR012459
6 · The paper itself

Abstract

aimsThe aim is to evaluate associations of lung function impairment with risk of incident heart failure (HF). METHODS AND

resultsData were pooled across eight US population-based cohorts that enrolled participants from 1987 to 2004. Participants with self-reported baseline cardiovascular disease were excluded. Spirometry was used to define obstructive [forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) <0.70] or restrictive (FEV1/FVC ≥0.70, FVC <80%) lung physiology. The incident HF was defined as hospitalization or death caused by HF. In a sub-set, HF events were sub-classified as HF with reduced ejection fraction (HFrEF; EF <50%) or preserved EF (HFpEF; EF ≥50%). The Fine-Gray proportional sub-distribution hazards models were adjusted for sociodemographic factors, smoking, and cardiovascular risk factors. In models of incident HF sub-types, HFrEF, HFpEF, and non-HF mortality were treated as competing risks. Among 31 677 adults, there were 3344 incident HF events over a median follow-up of 21.0 years. Of 2066 classifiable HF events, 1030 were classified as HFrEF and 1036 as HFpEF. Obstructive [adjusted hazard ratio (HR) 1.17, 95% confidence interval (CI) 1.07-1.27] and restrictive physiology (adjusted HR 1.43, 95% CI 1.27-1.62) were associated with incident HF. Obstructive and restrictive ventilatory defects were associated with HFpEF but not HFrEF. The magnitude of the association between restrictive physiology and HFpEF was similar to associations with hypertension, diabetes, and smoking.

conclusionLung function impairment was associated with increased risk of incident HF, and particularly incident HFpEF, independent of and to a similar extent as major known cardiovascular risk factors.

Indexed as

Heart FailureAdultHospitalizationHumansLungNational Heart, Lung, and Blood Institute (U.S.)PrognosisRisk FactorsStroke VolumeUnited StatesHeart failureLung functionProspective cohort studySpirometry

Identifiers

PMID35467708
PMCPMC9631233
OpenAlexW4224589302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.