ArticleNanoscale2022
High-yield halide-assisted synthesis of metal-organic framework UiO-based nanocarriers.
Article in Nanoscale, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Programmable nanomedicine via bioorthogonal molecular engineering.Nano convergence · 2026Review
- Clickable Polymer-Based Coatings for Modulating the Interaction of Metal-Organic Framework Nanocrystals with Living Cells.ACS applied materials & interfaces · 2025Article
- Ultrafast synthesis of zirconium-porphyrin framework nanocrystals from alkoxide precursors.Cell reports. Physical science · 2024Article
- Light-Responsive Nanoantennas Integrated into Nanoscale Metal-Organic Frameworks for Photothermal Drug Delivery.Small science · 2024Article
- Nanosized metal-organic frameworks as unique platforms for bioapplications.Chemical communications (Cambridge, England) · 2023Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synthesis of nanosized metal-organic frameworks (NMOFs) is requisite for their application as injectable drug delivery systems (DDSs) and other biorelevant purposes. Herein, we have critically examined the role of different synthetic parameters leading to the production of UiO-66 crystals smaller than 100 nm. Of note, we demonstrate the co-modulator role conferred by halide ions, not only to produce NMOFs with precise morphology and size, but also to significantly improve the reaction yield. The resulting NMOFs are highly crystalline and exhibit sustained colloidal stability in different biologically relevant media. As a proof of concept, these NMOFs were loaded with Rhodamine 6G (R6G), which remained trapped in most common biologically relevant media. When incubated with living mammalian cells, the R6G-loaded NMOFs were efficiently internalized and did not impair cell viability even at relatively high doses.
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Registered trials
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