Evidence map›Paper›PMID 35467427›Full record

ArticlemBio2022

Differential Functions of Individual Transcription Factor Binding Sites in the Tandem Repeats Found in Clinically Relevant

Sanjoy Paul, Paul E Verweij, Willem J G Melchers, W Scott Moye-Rowley

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Azole Resistance inOpen forum infectious diseases · 2026
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  8. Loss of a conserved C-terminal region of thebioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sanjoy PaulDepartment of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowagrid.214572.7, Iowa City, Iowa, USA.
Paul E VerweijDepartment of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID 0000-0002-8600-9860
Willem J G MelchersDepartment of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands.
W Scott Moye-RowleyDepartment of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowagrid.214572.7, Iowa City, Iowa, USA.ORCID 0000-0002-7163-1120
Radboud University Nijmegen · NLUniversity of Iowa · US

Funding

Elevated gene transcription of the cyp51A gene is essential for azole drug resistance in Aspergillus fumigatusR01AI143198 · NIAID · UNIVERSITY OF IOWA · PI W Scott Moye-Rowley · 2019 to 2026
$3.9M
Transcriptional networks governing A. fumigatus virulenceR01AI162802 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI FILLER, SCOTT G, MOYE-ROWLEY, W SCOTT · 2021 to 2025
$3.3M
NIAID NIH HHS R01 AI143198NIAID NIH HHS R01 AI162802
6 · The paper itself

Abstract

Aspergillus fumigatus is the major filamentous fungal pathogen in humans. The gold standard treatment of A. fumigatus is based on azole drug use, but the appearance of azole-resistant isolates is increasing at an alarming rate. The

Indexed as

Aspergillus fumigatusAzolesCytochrome P-450 Enzyme SystemFungal ProteinsAntifungal AgentsBinding SitesDrug Resistance, FungalMicrobial Sensitivity TestsPromoter Regions, GeneticTandem Repeat SequencesTranscription FactorsVoriconazoleAntifungal AgentsAzolescytochrome P-450 CYP51A, AspergillusCytochrome P-450 Enzyme SystemFungal ProteinsTranscription FactorsVoriconazoleAspergillus fumigatusazole resistancedrug resistance mechanismsmutational studiespromoterstranscription factors

Identifiers

PMID35467427
PMCPMC9239056
OpenAlexW4224820471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.