Evidence map›Paper›PMID 35467424›Full record

ArticlemBio2022

The Phenylacetic Acid Catabolic Pathway Regulates Antibiotic and Oxidative Stress Responses in Acinetobacter.

Anna J Hooppaw, Jenna C McGuffey, Gisela Di Venanzio, Juan C Ortiz-Marquez, Brent S Weber, Tasia Joy Lightly, Tim van Opijnen, Nichollas E Scott, Silvia T Cardona, Mario F Feldman

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Lineage-specific loss of the type VI secretion system inAntimicrobial agents and chemotherapy · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. New Insights intoPathogens (Basel, Switzerland) · 2026
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. The glutathione pathway is required for biofilm formation inCurrent research in microbial sciences · 2026
    Article
  12. Phenylacetic acid mediatesMicrobiology (Reading, England) · 2026
    Article
  13. IntracellularProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Antivirulence drugs against Acinetobacter baumannii: where do they stand?World journal of microbiology & biotechnology · 2025
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Anna J HooppawDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0002-6067-7705
Jenna C McGuffeyDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Gisela Di VenanzioDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Juan C Ortiz-MarquezBiology Department, Boston Collegegrid.208226.c, Chestnut Hill, Massachusetts, USA.
Brent S WeberDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Tasia Joy LightlyDepartment of Microbiology and Medical Microbiology, University of Manitobagrid.21613.37, Winnipeg, Manitoba, Canada.
Tim van OpijnenBiology Department, Boston Collegegrid.208226.c, Chestnut Hill, Massachusetts, USA.
Nichollas E ScottDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.
Silvia T CardonaDepartment of Microbiology and Medical Microbiology, University of Manitobagrid.21613.37, Winnipeg, Manitoba, Canada.ORCID 0000-0002-0629-8886
Mario F FeldmanDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0003-4497-0976
Washington University in St. Louis · USBoston College · USUniversity of Manitoba · CAThe University of Melbourne · AU

Funding

Molecular Insights into the Uropathogenesis of MDR Acinetobacter baumanniiR01AI144120 · NIAID · WASHINGTON UNIVERSITY · PI Mario Feldman · 2019 to 2026
$4.1M
INVESTIGATING TYPE VI SECRETION IN ACINETOBACTER BAUMANNII AND ITS INTERPLAY WITH ANTIBIOTIC RESISTAR01AI125363 · NIAID · WASHINGTON UNIVERSITY · PI FELDMAN, MARIO · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI125363NIAID NIH HHS R01 AI144120
6 · The paper itself

Abstract

The opportunistic pathogen Acinetobacter baumannii is responsible for a wide range of infections that are becoming increasingly difficult to treat due to extremely high rates of multidrug resistance. Acinetobacter's pathogenic potential is thought to rely on a "persist and resist" strategy that facilitates its remarkable ability to survive under a variety of harsh conditions. The

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsAnimalsBiofilmsDrug Resistance, Multiple, BacterialHydrogen PeroxideMiceOxidative StressPhenylacetatesProteomicsAnti-Bacterial AgentsHydrogen PeroxidePhenylacetatesphenylacetic acidAcinetobacterantibioticsgene regulationphenylacetic acidstress response

Identifiers

PMID35467424
PMCPMC9239106
OpenAlexW4224433984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.