ArticleScience China. Life sciences2022
Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets.
Article in Science China. Life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 45 citations in OpenAlex.
- Microencapsulation of a novelApplied and environmental microbiology · 2026Article
- A next-generation probiotic strain for gut health: Bacteroides cellulosilyticus LYH2 variant with anti-inflammatory and metabolic advantages.EBioMedicine · 2026Article
- EngineeredAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Bacteroides thetaiotaomicron: A symbiotic ally against diarrhea along with modulation of gut microbial ecological networks via tryptophan metabolism and AHR-Nrf2 signaling.Journal of advanced research · 2026Article
- Isatidis root polysaccharides ameliorates post-weaning diarrhea by promoting intestinal health and modulating the gut microbiota in piglets.The veterinary quarterly · 2025Article
- Prevotella copri alleviates diarrhea in weaning piglets through gut microbiota modulation and arachidonic acid-AHR-NRF2 pathway activation.Journal of animal science and biotechnology · 2025Article
- Glutathione contributes to alleviating hepatic injury via host-microbiome interaction and CAR-dependent pathway.Science China. Life sciences · 2025Article
- Bacterial infection in weaned piglets promotes diarrhea by inducing the NLRP3 inflammasome-pyroptosis pathway.Science China. Life sciences · 2025Article
- Unlocking the power of swine gut bacteria: newly isolated Blautia strain and its metabolites inhibit the replication of Salmonella Typhimurium in macrophages and alleviate DSS-induced colitis in mice.Journal of animal science and biotechnology · 2025Article
- Cinnamaldehyde supplementation in sows and their offspring: effects on colostrum and milk composition, performance, redox status and intestinal health.Journal of animal science and biotechnology · 2025Article
- Efficacy of Three Doses of Halquinol on Growth Performance, Diarrhea Incidence, Nutrient Digestibility, and Fecal Microbiome of Weaned Pigs.Animals : an open access journal from MDPI · 2025Article
- Comparison of fecal microbiota and metabolites in diarrheal piglets pre-and post-weaning.Frontiers in veterinary science · 2025Article
- Enteromorpha prolifera polysaccharide-Fe (III) complex promotes intestinal development as a new iron supplement.Science China. Life sciences · 2025Article
- Dietary supplementation with a blend composed of carvacrol, tannic acid derived from Castanea sativa and Glycyrrhiza glabra, and glycerides of medium chain fatty acids for weanling piglets raised in commercial farm.Veterinary research communications · 2024Article
- LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance, systemic inflammation, and mitochondrial morphology in a weaned piglet model.Science China. Life sciences · 2024Article
- Dietary nutrition, intestinal microbiota dysbiosis and post-weaning diarrhea in piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Dynamic changes in butyrate levels regulate satellite cell homeostasis by preventing spontaneous activation during aging.Science China. Life sciences · 2024Article
- AhR Activation Ameliorates Intestinal Barrier Damage in Immunostressed Piglets by Regulating Intestinal Flora and Its Metabolism.Animals : an open access journal from MDPI · 2024Article
- Amino acids in piglet diarrhea: Effects, mechanisms and insights.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Estimation of Protein and Amino Acid Requirements in Layer Chicks Depending on Dynamic Model.Animals : an open access journal from MDPI · 2024Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growing evidences show a direct link between diarrhea and disorders of gut microbiota in pigs. However, whether there are microbial markers associated with post-weaning diarrhea remains unknown. In the current study, we compared the microbial community, functions and metabolites between healthy weaned piglets (group H, n=7) and piglets with post-weaning diarrhea (group D, n=7), in order to find out diarrhea associated microbial markers. Each of 7 fecal samples was collected from H and D piglets (weaned at 21 d and sampled at 26 d). The metagenomic and untargeted metabolomic analysis revealed that the microbial composition, function and metabolic profile in D pigs was considerably reshaped, including the reduced abundance and number of Bacteroides, which significantly correlated with the diarrhea status of host. The carbohydrate metabolism, biosynthesis and metabolism, lipid metabolism, amino acid metabolism, and the activity of glycan and carbohydrates digestion related enzymes showed extensively down-regulated in D pigs compared with H pigs. Diarrhea significantly changed the metabolic profiles of fecal microbiota, and most of the altered metabolites were negatively or positively correlated with the change in the abundance of Bacteroides. In conclusion, the lower abundance of Bacteroides and its associated metabolic dysfunction may be regarded as microbial markers of physiological post-weaning diarrhea in piglets.
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