Evidence map›Paper›PMID 35467236›Full record

ReviewProbiotics and antimicrobial proteins2022

Limosilactobacillus fermentum, Current Evidence on the Antioxidant Properties and Opportunities to be Exploited as a Probiotic Microorganism.

Luciana Caroline Paulino do Nascimento, Diego Cabral Lacerda, Diorginis José Soares Ferreira, Evandro Leite de Souza, José Luiz de Brito Alves

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Probiotics and antimicrobial proteins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07530575 (Biological Effects of the Consumption of Limosilactobacillus Fermentum CRL 1446 - CONICET in Volunteers With Cardiovascular Risk Factors), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07530575 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Biological Effects of the Consumption of Limosilactobacillus Fermentum CRL 1446 - CONICET in Volunteers With Cardiovascular Risk Factors

TypeinterventionalSponsorPINER Pastor Manfredi WineryRan2026 to 2027Enrolled80ConditionsDisbiosis, Obesity, Overweight (BMI > 25), Hypertension (Without Type 2 Diabetes Mellitus)ArmsLimosilactobacillus fermentum 1446 CRL CONICET 2.20E+9 CFU, Placebo (inert excipient)
3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Foods (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Article
  7. Canine-derivedCurrent research in microbial sciences · 2025
    Article
  8. Review
  9. Review
  10. Optimizing Cellulase-Antioxidants (Basel, Switzerland) · 2024
    Article
  11. Article
  12. A Mix of Potentially ProbioticMicroorganisms · 2024
    Article
  13. Article
  14. Gallnut tannic acid alleviates gut damage induced byFrontiers in veterinary science · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Environment-Related Genes Analysis ofFoods (Basel, Switzerland) · 2022
    Article
  19. Potential role ofWorld journal of diabetes · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luciana Caroline Paulino do NascimentoDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, Campus I - João Pessoa, Paraíba, Brazil.
Diego Cabral LacerdaDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, Campus I - João Pessoa, Paraíba, Brazil.
Diorginis José Soares FerreiraColegiado de Educação Física, Federal University of São Franscisco Valley, Petrolina, Brazil.
Evandro Leite de SouzaDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, Campus I - João Pessoa, Paraíba, Brazil.
José Luiz de Brito AlvesDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, Campus I - João Pessoa, Paraíba, Brazil. jose_luiz_61@hotmail.com.ORCID 0000-0003-4696-3809

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unbalance in the production and removal of oxygen-reactive species in the human organism leads to oxidative stress, a physiological condition commonly linked to the occurrence of cancer, neurodegenerative, inflammatory, and metabolic disorders. The implications of oxidative stress in the gut have been associated with gut microbiota impairments and gut dysbiosis. Some lactobacilli strains have shown an efficient antioxidant system capable of protecting against oxidative stress and related-chronic diseases. Recently, in vitro and experimental studies and some clinical trials have demonstrated the efficacy of the administration of various Limosilactobacillus fermentum strains to modulate beneficially the host antioxidant system resulting in the amelioration of a variety of systemic diseases phenotypes. This review presents and discusses the currently available studies on identifying L. fermentum strains with anti-oxidant properties, their sources, range of the administered doses, and duration of the intervention in experiments with animals and clinical trials. This review strives to serve as a relevant and well-cataloged reference of L. fermentum strains with capabilities of inducing anti-oxidant effects and health-promoting benefits to the host, envisaging their broad applicability to disease control.

Indexed as

Gastrointestinal MicrobiomeLimosilactobacillus fermentumProbioticsAnimalsAntioxidantsDysbiosisHumansAntioxidantsAntioxidant capacityLimosilactobacillus fermentumOxidative stressProbiotic

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.