ArticleEJNMMI physics2022
Development of a dynamic myocardial perfusion phantom model for tracer kinetic measurements.
Article in EJNMMI physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- Validation of quantitative transport mapping (QTM) with an ex vivo perfused liver model.Magnetic resonance in medicine · 2025Article
- A Review on the Use of Imaging Biomarkers in Oncology Clinical Trials: Quality Assurance Strategies for Technical Validation.Tomography (Ann Arbor, Mich.) · 2023Review
- Assessment of resting myocardial blood flow in regions of known transmural scar to confirm accuracy and precision of 3D cardiac positron emission tomography.EJNMMI research · 2023Article
- A Multimodality Myocardial Perfusion Phantom: Initial Quantitative Imaging Results.Bioengineering (Basel, Switzerland) · 2022Article
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Authors and funding
7 authors at 3 institutions in 1 country.
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Abstract
backgroundAbsolute myocardial perfusion imaging (MPI) is beneficial in the diagnosis and prognosis of patients with suspected or known coronary artery disease. However, validation and standardization of perfusion estimates across centers is needed to ensure safe and adequate integration into the clinical workflow. Physical myocardial perfusion models can contribute to this clinical need as these can provide ground-truth validation of perfusion estimates in a simplified, though controlled setup. This work presents the design and realization of such a myocardial perfusion phantom and highlights initial performance testing of the overall phantom setup using dynamic single photon emission computed tomography.
resultsDue to anatomical and (patho-)physiological representation in the 3D printed myocardial perfusion phantom, we were able to acquire 22 dynamic MPI datasets in which
conclusionThe presented myocardial perfusion phantom is a first step toward ground-truth validation of multimodal, absolute MPI applications in the clinical setting. Its dedicated and 3D printed design enables tracer kinetic measurement, including time activity curve and potentially compartmental myocardial blood flow analysis.
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