Evidence map›Paper›PMID 35467062›Full record

ArticleCancer science2022

Association of Nrf2 expression and mutation with Weiss and Helsinki scores in adrenocortical carcinoma.

Takao Kamai, Satoshi Murakami, Kyoko Arai, Kazuyuki Ishida, Toshiki Kijima

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Takao KamaiDepartment of Urology, Dokkyo Medical University, Mibu, Tochigi, Japan.ORCID https://orcid.org/0000-0002-7086-6964
Satoshi MurakamiDepartment of Urology, Dokkyo Medical University, Mibu, Tochigi, Japan.
Kyoko AraiDepartment of Urology, Dokkyo Medical University, Mibu, Tochigi, Japan.
Kazuyuki IshidaDepartment of Diagnostic Pathology, Dokkyo Medical University, Mibu, Tochigi, Japan.
Toshiki KijimaDepartment of Urology, Dokkyo Medical University, Mibu, Tochigi, Japan.
Dokkyo Medical University · JP

Funding

Japanese Science Progress Society KAKENHI 20K09546
6 · The paper itself

Abstract

Adrenocortical carcinoma (ACC) is a rare malignant tumor. Genetic abnormalities that may represent therapeutic targets and prognostic factors in ACC remain unclear. Besides being one of the main cellular defense mechanisms that regulates antioxidant pathways for detoxifying reactive oxygen species (ROS), the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) promotes tumor proliferation by increasing metabolic activity. In surgical specimens from 12 cases of nonmetastatic ACCs and nine cases of benign adrenocortical adenoma (ACA), we investigated gene mutation and protein expressions for Nrf2 and the preoperative maximum standard glucose uptake (SUVmax) on [

Indexed as

Adrenal Cortex NeoplasmsAdrenocortical AdenomaAdrenocortical CarcinomaNF-E2-Related Factor 2HumansMutationPositron-Emission TomographyNFE2L2 protein, humanNF-E2-Related Factor 2[18F]fluorodeoxy-glucose positron emission tomography (18F-FDG-PET)adrenocortical carcinomanuclear factor E2-related factor 2 (Nrf2)p53Weiss and Helsinki scores

Identifiers

PMID35467062
PMCPMC9277251
OpenAlexW4224435819

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.