Evidence map›Paper›PMID 35466946›Full record

ArticleJournal of neuromuscular diseases2022

Step Activity Monitoring in Boys with Duchenne Muscular Dystrophy and its Correlation with Magnetic Resonance Measures and Functional Performance.

Kavya S Nair, Donovan J Lott, Sean C Forbes, Alison M Barnard, Rebecca J Willcocks, Claudia R Senesac, Michael J Daniels, Ann T Harrington, Gihan I Tennekoon, Kirsten Zilke and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuromuscular diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01484678 (Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01484678 recruitingnot on this map

Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy

TypeobservationalSponsorUniversity of FloridaRan2020 to 2026Enrolled550ConditionsDuchenne Muscular Dystrophy, Becker Muscular Dystrophy
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kavya S NairDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
Donovan J LottDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
Sean C ForbesDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
Alison M BarnardDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
Rebecca J WillcocksDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
Claudia R SenesacDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
Michael J DanielsDepartment of Statistics, University of Florida, Gainesville, FL, USA.
Ann T HarringtonCenter for Rehabilitation, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Gihan I TennekoonDepartment of Neurology and Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kirsten ZilkeDepartment of Pediatrics and Neurology, Oregon Health & Science University, Portland, OR, USA.
Erika L FinangerDepartment of Pediatrics and Neurology, Oregon Health & Science University, Portland, OR, USA.
Richard S FinkelCenter for Experimental Neurotherapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
William D RooneyAdvanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA.
Glenn A WalterDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA.
Krista VandenborneDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.

Funding

Magnetic Resonance Imaging and Biomarkers for Muscular DystropyR01AR056973 · NIAMS · UNIVERSITY OF FLORIDA · PI VANDENBORNE, KRISTA H · 2010 to 2024
$20.2M
Rehabilitation Research Career Development ProgramK12HD055929 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BROWN, DAVID A · 2007 to 2021
$11.7M
Breathing Research and Therapeutics (BREATHE)T32HL134621 · NHLBI · UNIVERSITY OF FLORIDA · PI Gordon S. Mitchell · 2017 to 2026
$3.4M
NHLBI NIH HHS T32 HL134621NIAMS NIH HHS R01 AR056973NICHD NIH HHS K12 HD055929
6 · The paper itself

Abstract

backgroundMuscles of boys with Duchenne muscular dystrophy (DMD) are progressively replaced by fatty fibrous tissues, and weakness leads to loss of ambulation (LoA). Step activity (SA) monitoring is a quantitative measure of real-world ambulatory function. The relationship between quality of muscle health and SA is unknown in DMD.

objectiveTo determine SA in steroid treated boys with DMD across various age groups, and to evaluate the association of SA with quality of muscle health and ambulatory function.

methodsQuality of muscle health was measured by magnetic resonance (MR) imaging transverse magnetization relaxation time constant (MRI-T2) and MR spectroscopy fat fraction (MRS-FF). SA was assessed via accelerometry, and functional abilities were assessed through clinical walking tests. Correlations between SA, MR, and functional measures were determined. A threshold value of SA was determined to predict the future LoA.

resultsThe greatest reduction in SA was observed in the 9- < 11years age group. SA correlated with all functional and MR measures.10m walk/run test had the highest correlation with SA. An increase in muscle MRI-T2 and MRS-FF was associated with a decline in SA. Two years prior to LoA, SA in boys with DMD was 32% lower than age matched boys with DMD who maintained ambulation for more than two-year period. SA monitoring can predict subsequent LoA in Duchenne, as a daily step count of 3200 at baseline was associated with LoA over the next two-years.

conclusionSA monitoring is a feasible and accessible tool to measure functional capacity in the real-world environment.

Indexed as

Muscular Dystrophy, DuchenneHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMuscle, SkeletalPhysical Functional Performance10m walk/run testduchenne muscular dystrophyfat fractionMRIStep activity

Identifiers

PMID35466946
PMCPMC9257666

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.