ArticleThe Journal of international medical research2022
Effect of midazolam on delirium in critically ill patients: a propensity score analysis.
Article in The Journal of international medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Effect of Remimazolam vs Midazolam on Early Postoperative Cognitive Recovery in Elderly Patients Undergoing Dental Extraction: A Prospective Randomized Controlled Study.Drug design, development and therapy · 2024Trial
- Propofol injection discomfort recall after monitored anesthesia care or general anesthesia: a prospective observational cohort study.Journal of anesthesia · 2026Article
- The 2026 World Delirium Awareness Day Survey: Findings From Turkish Intensive Care Units.Nursing in critical care · 2026Article
- A multicentre survey of Australian intensivists on optimal use of midazolam for sedation.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Early goal-directed sedation with dexmedetomidine is associated with lower delirium rate in mechanically ventilated patients.BMC anesthesiology · 2026Article
- Isoflurane for difficult sedation in critically ill children: a retrospective analysis in a mixed pediatric intensive care population.Frontiers in pediatrics · 2026Article
- Sleep Quality, Circadian Rhythm Stability and Changes in Delirium State in Predicting Mortality Risk in Intensive Care Unit Patients: A Prospective Observational Study.Nursing in critical care · 2025Observational
- Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial.Therapeutics and clinical risk management · 2025Article
- Article
- Dexmedetomidine administration is associated with a reduced risk of ICU mortality in critically ill patients with ischemic stroke.Frontiers in neurology · 2025Article
- Incidence of Delirium in ICU Patients With and Without COVID-19 in a Costa Rican Hospital.Cureus · 2024Article
- Midazolam for Post-Arrest Sedation in Pre-Hospital Emergency Care—a Multicenter Propensity Score Analysis.Deutsches Arzteblatt international · 2024Observational
- Phenobarbital versus benzodiazepines in alcohol withdrawal syndrome.Neuropsychopharmacology reports · 2023Article
- Agitation is a Common Barrier to Recovery of ICU Patients.Journal of intensive care medicine · 2023Article
- Can Lemborexant for Insomnia Prevent Delirium in High-Risk Patients with Pancreato-Biliary Disease after Endoscopic Procedures under Deep Sedation?Journal of clinical medicine · 2022Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo observe the association between exposure to midazolam within 24 hours prior to delirium assessment and the risk of delirium.
methodsWe performed a systematic cohort study with two sets of cohorts to estimate the relative risks of outcomes among patients administered midazolam within 24 hours prior to delirium assessment. Propensity score matching was performed to generate a balanced 1:1 matched cohort and identify potential prognostic factors. The outcomes included the odds of delirium, mortality, length of intensive care unit stay, length of hospitalization, and odds of being discharged home.
resultsA total of 78,364 patients were included in this study, of whom 22,159 (28.28%) had positive records. Propensity matching successfully balanced covariates for 9348 patients (4674 per group). Compared with no administration of midazolam, midazolam administration was associated with a significantly higher risk of delirium, higher mortality, and a longer intensive care unit stay. Patients treated with midazolam were relatively less likely to be discharged home. There was no significant difference in hospitalization duration.
conclusionsMidazolam may be an independent risk factor for delirium in critically ill patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.