Evidence map›Paper›PMID 35466691›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2022

T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling.

Subburaman Mohan, Chandrasekhar Kesavan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Subburaman MohanMusculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California.
Chandrasekhar KesavanMusculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California.ORCID 0000-0003-0685-0367
Loma Linda University · US

Funding

Transgenic Approaches to Evaluate IGF-I Role in Peak BMDR01AR048139 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH &EDUC · PI MOHAN, SUBBURAMAN · 2003 to 2025
$4.7M
Transgenic Approaches to Evalute IGF-1 Role in Peak BMDR56AR048139 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · PI MOHAN, SUBBURAMAN · 2008 to 2008
$258k
BLRD Research Career Scientist Award ApplicationIK6BX005381 · VA · VA LOMA LINDA HEALTHCARE SYSTEM · PI SUBBURAMAN MOHAN · 2021 to 2026
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BLRD VA IK6 BX005381NIAMS NIH HHS R01 AR048139NIAMS NIH HHS R56 AR048139
6 · The paper itself

Abstract

T-cell-like factor (TCF)7l2, a key effector of canonical Wnt signaling, is highly expressed in bone but nothing is known about its role in regulating osteoblast function. To test this, we generated mice with conditional disruption of

Indexed as

beta CateninOsteoblastsTranscription Factor 7-Like 2 ProteinAnimalsCell DifferentiationCell HypoxiaCell LineMiceMice, KnockoutWnt Signaling PathwayX-Ray Microtomographybeta CateninTcf7l2 protein, mouseTranscription Factor 7-Like 2 ProteinHif1αmechanical loadingosteoblastTcfTcf7l2

Identifiers

PMID35466691
PMCPMC9169825
OpenAlexW4224466353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.