Evidence map›Paper›PMID 35466586›Full record

ArticlePharmacology research & perspectives2022

Docosahexaenoic acid and eicosapentaenoic acid strongly inhibit prostanoid TP receptor-dependent contractions of guinea pig gastric fundus smooth muscle.

Keyue Xu, Miyuki Shimizu, Chika Murai, Miki Fujisawa, Daichi Ito, Noboru Saitoh, Yutaka Nakagome, Mio Yamashita, Azusa Murata, Shunya Oikawa and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Keyue XuDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Miyuki ShimizuDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Chika MuraiDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Miki FujisawaDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Daichi ItoDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Noboru SaitohDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Yutaka NakagomeDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Mio YamashitaDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Azusa MurataDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Shunya OikawaDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Guanghan OuDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Kento YoshiokaDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.ORCID 0000-0003-1701-3759
Keisuke ObaraDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.ORCID 0000-0001-9226-4086
Yoshio TanakaDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.ORCID 0000-0002-8341-3809
Toho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inhibitory effects of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and linoleic acid (LA) on the contractions induced by five prostanoids and U46619 (a TP receptor agonist) were examined in guinea pig gastric fundus smooth muscle (GFSM). Tension changes were isometrically measured, and the mRNA expression of prostanoid receptors was measured by RT-qPCR. DHA and EPA significantly inhibited contractions induced by the prostanoids and U46619, whereas LA inhibited those induced by prostaglandin D

Indexed as

Docosahexaenoic AcidsEicosapentaenoic Acid15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAnimalsCalcium Channels, L-TypeGastric FundusGuinea PigsMuscle, SmoothProstaglandinsReceptors, ThromboxaneRNA, MessengerVerapamil15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidCalcium Channels, L-TypeDocosahexaenoic AcidsEicosapentaenoic AcidProstaglandinsReceptors, ThromboxaneRNA, MessengerVerapamildocosahexaenoic acideicosapentaenoic acidgastric fundus smooth musclen−3 polyunsaturated fatty acidsprostanoidsprostanoid TP receptor

Identifiers

PMID35466586
PMCPMC9035583
OpenAlexW4224318133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.