Evidence map›Paper›PMID 35466486›Full record

Trial reportClinical psychology & psychotherapy2022

Durability of treatment effects following internet-delivered cognitive behavioural therapy for depression and anxiety delivered within a routine care setting.

Jorge E Palacios, Angel Enrique, Olwyn Mooney, Simon Farrell, Caroline Earley, Daniel Duffy, Nora Eilert, Siobhan Harty, Ladislav Timulak, Derek Richards

Abstract readRandomized Controlled TrialPragmatic Clinical Trial
In one paragraph

Trial report in Clinical psychology & psychotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jorge E PalaciosSilverCloud Science, SilverCloud Health, Dublin, Ireland.ORCID https://orcid.org/0000-0002-2103-5507
Angel EnriqueSilverCloud Science, SilverCloud Health, Dublin, Ireland.ORCID https://orcid.org/0000-0003-0585-4008
Olwyn MooneySilverCloud Science, SilverCloud Health, Dublin, Ireland.ORCID https://orcid.org/0000-0002-3225-1571
Simon FarrellSilverCloud Science, SilverCloud Health, Dublin, Ireland.
Caroline EarleySilverCloud Science, SilverCloud Health, Dublin, Ireland.
Daniel DuffySilverCloud Science, SilverCloud Health, Dublin, Ireland.ORCID https://orcid.org/0000-0001-9722-0437
Nora EilertSilverCloud Science, SilverCloud Health, Dublin, Ireland.ORCID https://orcid.org/0000-0003-3184-3599
Siobhan HartySilverCloud Science, SilverCloud Health, Dublin, Ireland.ORCID https://orcid.org/0000-0001-7560-9185
Ladislav TimulakE-mental Health Research Group, School of Psychology, Aras an Phiarsaigh, Trinity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0003-2785-0753
Derek RichardsSilverCloud Science, SilverCloud Health, Dublin, Ireland.ORCID https://orcid.org/0000-0003-0871-4078

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate post-treatment relapse and remission rates 3, 6 and 9 months after completion of an acute phase of a clinician-supported internet-delivered cognitive-behavioural therapy (iCBT) for anxiety and depressive symptoms, within a routine care setting.

methodSecondary analysis from a 12-month pragmatic randomized-controlled trial delivered within the Improving Access to Psychological Therapies (IAPT) programme in England. Participants in the intervention arm were included if they met criteria for reliable recovery from depression (PHQ-9) and anxiety (GAD-7) at post-treatment assessment. Survival analysis was used to assess durability of treatment effects and determine predictors to relapse at 3-, 6- and 9-month follow-up. Hazard ratios predicting time-to-relapse were estimated with semi-parametric Cox proportional hazards model.

resultsOf the 241 participants in the intervention arm, 89 participants met the criteria for reliable recovery from depression and anxiety at the post-treatment assessment. Of these 89 eligible cases, 29.2% relapsed within the 9-month period, with 70.8% remaining in remission at 9 months post-treatment. Of those who relapsed, 53.8% experienced a relapse of depression and anxiety; 7.7% experienced a relapse of depression only; and 38.4% experienced a relapse of anxiety only. Younger age, having a long-term condition, and residual symptoms of anxiety at end-of-treatment were all significant predictors of relapse.

conclusionsThis study is the first to explore the remission and relapse rates after an acute phase of iCBT treatment, within a routine, stepped-care setting. The results add to the scarce literature on the durability of the effects of iCBT treatment in routine care settings, where patients are not typically followed up after receiving a completed course of treatment.

Indexed as

Cognitive Behavioral TherapyDepressionAnxietyChronic DiseaseHumansInternetRecurrenceTreatment OutcomeanxietydepressioniCBTrelapseremission

Identifiers

PMID35466486
PMCPMC9790710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.