ArticleContemporary clinical dentistry
Association of Salivary Statherin, Calcium, and Proline-Rich Proteins: A Potential Predictive Marker of Dental Caries.
Article in Contemporary clinical dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- The Cariostatic Mechanisms of Fluoride-An Updated Review.Dentistry journal · 2026Review
- Salivary proteins, proteases, and disease pathophysiology in oral health and precision diagnostics: a narrative review.Frontiers in dental medicine · 2026Review
- CHANGES IN SALIVARY PROTEOME WITH REGARD TO PAIN-RELATED PROTEINS FOLLOWING FIXED ORTHODONTIC APPLIANCE PLACEMENT.Acta clinica Croatica · 2025Article
- Combined effect of dietary calcium consumption and physical activity on dental caries in children and adolescents: a study of the NHANES database.BMC oral health · 2024Article
- Role of Salivary Biomarkers in Diagnosis and Detection of Dental Caries: A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Background: Salivary factors modulate the balanced dynamic mineralization process of the dental enamel. Salivary proteins such as statherin and acidic proline-rich proteins (PRPs) protect oral surfaces by regulating oral calcium homeostasis and remineralization of enamel. Thus, they possibly play vital roles in dental caries. Aim: The present study aims to find the association of salivary statherin, proline-rich protein, and calcium levels with dental caries. Methods: A descriptive, cross-sectional study was conducted among 188 healthy participants (age between 18 and 50 years), from dental clinic of MAHSA University, Malaysia. Dental caries was measured using standard WHO criteria. Stimulated whole mouth saliva was collected, and salivary statherin, acidic PRP (aPRP), and calcium levels were estimated using ELISA Kit and calorimetric assay kit, respectively. Data were analyzed using Spearman's rho and Pearson's correlation coefficient (SPSS statistical package-version 25.0) to find correlation of salivary statherin, calcium, and proline-rich protein levels with dental caries. Results: A statistically significant ( Conclusion: Salivary statherin and aPRP levels appear to perform mutually complementing functions and thus may have potential role in the maintenance of tooth integrity.
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