Evidence map›Paper›PMID 35466277›Full record

ArticleAntibodies (Basel, Switzerland)2022

Effects of Monovalent Salt on Protein-Protein Interactions of Dilute and Concentrated Monoclonal Antibody Formulations.

Amy Y Xu, Nicholas J Clark, Joseph Pollastrini, Maribel Espinoza, Hyo-Jin Kim, Sekhar Kanapuram, Bruce Kerwin, Michael J Treuheit, Susan Krueger, Arnold McAuley and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibodies (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Amy Y XuNIST Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, MD 20899, USA.ORCID 0000-0002-4071-1750
Nicholas J ClarkNIST Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, MD 20899, USA.
Joseph PollastriniAmgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Maribel EspinozaAmgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Hyo-Jin KimAmgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Sekhar KanapuramAmgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Bruce KerwinAmgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Michael J TreuheitAmgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Susan KruegerNIST Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, MD 20899, USA.ORCID 0000-0002-5774-5834
Arnold McAuleyAmgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Joseph E CurtisNIST Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, MD 20899, USA.ORCID 0000-0001-5818-295X
Amgen (United States) · USNational Institute of Standards and Technology · US

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
Engineering and Physical Sciences Research Council EP/K039121/1National Science Foundation DMR-1508249National Science Foundation DMR-1829070National Sleep Foundation CHE-1265821NIGMS NIH HHS P30 GM124166NIH HHS 1-P30-GM124166-01A1NIST DOC NIST biomanufacturing initiative
6 · The paper itself

Abstract

In this study, we used sodium chloride (NaCl) to extensively modulate non-specific protein-protein interactions (PPI) of a humanized anti-streptavidin monoclonal antibody class 2 molecule (ASA-IgG2). The changes in PPI with varying NaCl (

Indexed as

formulation developmentprotein-protein interactionsprotein stabilitysmall-angle scattering

Identifiers

PMID35466277
PMCPMC9036246
OpenAlexW4220743448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.