ArticleBiomimetics (Basel, Switzerland)2022
Strong and Elastic Chitosan/Silk Fibroin Hydrogels Incorporated with Growth-Factor-Loaded Microspheres for Cartilage Tissue Engineering.
Article in Biomimetics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Smart functionalized cartilage repair microspheres: Concepts and applications.Materials today. Bio · 2026Review
- Overview of Silk Fibroin Injectable Hydrogels: Advances and Applications in Regenerative Medicine.Advanced healthcare materials · 2026Review
- Functionalization of Photocrosslinkable GelMA Hydrogel With Metal Oxides for Direct Pulp Capping.BioMed research international · 2026Article
- PRP and hypertonic glucose injections improve outcomes in patients with early- to middle-stage knee osteoarthritis: a multicenter retrospective study.BMC musculoskeletal disorders · 2025Article
- Controlled Fabrication of pH-Visualised Silk Fibroin-Sericin Dual-Network Hydrogels for Urine Detection in Diapers.Gels (Basel, Switzerland) · 2025Article
- Article
- Silk fibroin-based hydrogels for cartilage organoids in osteoarthritis treatment.Theranostics · 2025Review
- Tyrosinases: a family of copper-containing metalloenzymes.Chemtexts · 2024Article
- Kartogenin delivery systems for biomedical therapeutics and regenerative medicine.Drug delivery · 2023Review
- Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications.Biomimetics (Basel, Switzerland) · 2023Review
- Applications of Chitosan in Surgical and Post-Surgical Materials.Marine drugs · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
An emulsification method was developed for fabricating core-shell microspheres with a thick shell layer. Kartogenin (KGN) and platelet-derived growth factor BB (PDGF-BB) were respectively loaded into the core portion and the shell layer of the microspheres with high loading efficiency. The optimally built microspheres were combined with chitosan (CH) and silk fibroin (SF) to construct a new type of composite hydrogel with enhanced strength and elasticity, using genipin or/and tyrosinase as crosslinkers for the intended use in cartilage tissue engineering. The composite hydrogels were found to be thermo-responsive at physiological temperature and pH with well-defined injectability. Rheological measurements revealed that they had an elastic modulus higher than 6 kPa with a high ratio of elastic modulus to viscous modulus, indicative of their mechanically strong features. Compressive measurements demonstrated that they possessed well-defined elasticity. In addition, some gels had the ability to administer the temporal separation release of PDGF-BB and KGN in an approximately linear manner for several weeks. The released PDGF-BB was found to be bioactive based on its effects on Balb/c 3T3 cells. The composite gels supported the growth of seeded chondrocytes while preserving their phenotype. The results suggest that these composite gels have the potential for endogenous cartilage repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.