ArticleNeurologia medico-chirurgica2022
Coagulopathy and Traumatic Brain Injury: Overview of New Diagnostic and Therapeutic Strategies.
Article in Neurologia medico-chirurgica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Association between fresh frozen plasma transfusion and mortality stratified by Glasgow Coma Scale scores in isolated traumatic brain injury: a nationwide cohort study in Japan.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Risk factors for coagulation dysfunction in traumatic brain injury patients: A single-center retrospective cohort study.Medicine · 2026Article
- Trauma-Induced Coagulopathy in Rat Models: Assessing Hemostatic Changes in Mild and Severe Traumatic Brain Injuries.Neurology international · 2026Article
- Risk factors for prognosis in patients with traumatic brain injury: A retrospective observational study.Medicine · 2026Observational
- Intracranial pressure, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, C-reactive protein, and D-dimer mortality predictors in isolated severe traumatic brain injury.Surgical neurology international · 2026Article
- Partly intraoperative cell salvage in pediatric craniocerebral trauma: effects on coagulation function, allogeneic blood requirements, and clinical outcomes - a propensity score-matched retrospective cohort study.Frontiers in pediatrics · 2026Article
- Article
- Effects of coagulation dysfunction and platelet changes on rebleeding and prognosis in acute subdural hematoma.American journal of translational research · 2026Article
- Predictors of Massive Transfusion in Patients With Hollow Organ Injury After Blunt Multiple Trauma: A Cohort of Blunt Bowel Mesenteric Injury.Emergency medicine international · 2026Article
- The Association of the Neutrophil-to-Lymphocyte Ratio and the D-dimer-to-Albumin Ratio with Deep Vein Thrombosis in Patients with Spontaneous Intracerebral Hemorrhage.International journal of general medicine · 2026Article
- Association of the prealbumin-albumin nutritional index with short-term mortality in hospitalized patients with traumatic brain injury.Frontiers in nutrition · 2026Article
- Potential Predictors of Mortality in Adults with Severe Traumatic Brain Injury.Brain sciences · 2025Article
- Transfusion biomaterials for hemostasis.Journal of thrombosis and haemostasis : JTH · 2025Review
- Developing practical machine learning survival models to identify high-risk patients for in-hospital mortality following traumatic brain injury.Scientific reports · 2025Article
- Evaluating the Efficacy of Longitudinal Coagulation Biomarkers to Predict in-Hospital Death in Comatose TBI Patients: A Time-Dependent Roc Curve Approach.Medical journal of the Islamic Republic of Iran · 2025Article
- Prognostic Factors and Initial Treatment Strategies for Patients with Head Trauma and Vital Signs of Shock.Neurotrauma reports · 2025Article
- Article
- Development and validation of a nomogram for predicting mortality in patients with acute severe traumatic brain injury: A retrospective analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Traumatic Brain Injury in Patients under Anticoagulant Therapy: Review of Management in Emergency Department.Journal of clinical medicine · 2024Review
- Effect of low fibrinogen level on in-hospital mortality and 6-month functional outcome of TBI patients, a single center experience.Neurosurgical review · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coagulopathy is a common sequela of traumatic brain injury. Consumptive coagulopathy and secondary hyperfibrinolysis are associated with hypercoagulability. In addition, fibrinolytic pathways are hyperactivated as a result of vascular endothelial cell damage in the injured brain. Coagulation and fibrinolytic parameters change dynamically to reflect these pathologies. Fibrinogen is consumed and degraded after injury, with fibrinogen concentrations at their lowest 3-6 h after injury. Hypercoagulability causes increased fibrinolytic activity, and plasma levels of D-dimer increase immediately after traumatic brain injury, reaching a maximum at 3 h. Owing to disseminated intravascular coagulation in the presence of fibrinolysis, the bleeding tendency is highest within the first 3 h after injury, and often a condition called "talk and deteriorate" occurs. In neurointensive care, it is necessary to measure coagulation and fibrinolytic parameters such as fibrinogen and D-dimer routinely to predict and prevent the development of coagulopathy and its negative outcomes. Currently, the only evidence-based treatment for traumatic brain injury with coagulopathy is tranexamic acid in the subset of patients with mild-to-moderate traumatic brain injury. Coagulation and fibrinolytic parameters should be closely monitored, and treatment should be considered on a patient-by-patient basis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.