ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2022
The Evaluation of Thiol/Disulfide Homeostasis and Oxidative DNA Damage in Patients with Obsessive Compulsive Disorder.
Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Trial
- Pharmacogenomic-guided prescribing and polypharmacy across age groups in obsessive-compulsive disorder: a retrospective study.BMC psychiatry · 2026Article
- Choroidal Vascularity Index in Schizophrenia Compared to Healthy Subjects: A Cross-Sectional Study.Health science reports · 2026Article
- A Diagnosis Model of Typhoon-Related Post-Traumatic Stress Disorder Based on Fixel-Based Analysis in Machine Learning.Brain and behavior · 2026Article
- Can Oxidative Stress Biomarkers Differentiate Trichotillomania from Obsessive-Compulsive Disorder and Healthy Controls?Journal of molecular neuroscience : MN · 2025Article
- Mediterranean Diet Adherence and Acne Vulgaris Severity in an Iranian Population: A Case-Control Study.Health science reports · 2025Article
- Oxidative Imbalance in Conversion Disorder: Evidence from Thiol-Disulphide Homeostasis Disruption.Neuropsychiatric disease and treatment · 2025Article
- Remission of obsessive-compulsive disorder using ketogenic metabolic therapy in support of exposure and response prevention: a retrospective case report.Frontiers in psychiatry · 2025Article
- Heavy Metal and Thiol/Disulfide in Children with Attention-Deficit and Hyperactivity Disorder.Psychiatry and clinical psychopharmacology · 2024Article
- Thiol-disulphide Homeostasis in Patients with Schizophrenia: The Potential Biomarkers of Oxidative Stress in Acute Exacerbation of Schizophrenia.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Evaluation of Thiol/Disulfide Interrelation in Major Depressive Disorder.Alpha psychiatry · 2023Article
- Effect Modification of Cortisol on the Associations Between Obsessive-Compulsive Symptoms on Suicidality in Patients With Acute Coronary Syndrome.Psychiatry investigation · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: In this study, we aimed to examine thiol/disulfide homeostasis and oxidative DNA damage in patients with OCD and compare them with healthy controls. Methods: Thirty-five patients previously diagnosed with OCD in Van Yuzuncu Yil University Department of Psychiatry and thirty-three healthy volunteers were included in the study. The severity of the symptoms was measured using the Yale-Brown Obsessive-Compulsive Scale. Five ml of blood samples were taken from the patient and control groups. The samples were stored at appropriate conditions until use. Leukocyte DNA was isolated and the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and deoxyguanosine were detected to assess the oxidative DNA damage. The level of oxidative DNA damage was expressed as 8-OHdG/10 Results: were given as percentages. Results: The total and native thiol levels in patients with OCD were significantly lower, and the disulfide levels were significantly higher in patients with OCD than healthy control subjects. In addition, 8-OHdG, an indicator of DNA damage, was significantly lower in the control group compared to the patient group. Conclusion: Increased levels of disulfide/native thiol and disulfide/total thiol in patients with OCD show that levels of oxidative stress were elevated and therefore, higher 8-OHdG levels in patients with OCD is a marker of oxidative DNA damage.
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