Evidence map›Paper›PMID 35465862›Full record

ArticleEpidemiology and psychiatric sciences2022

Sleep disturbance and psychiatric disorders: a bidirectional Mendelian randomisation study.

Xiaohui Sun, Bin Liu, Sitong Liu, David J H Wu, Jianming Wang, Yi Qian, Ding Ye, Yingying Mao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and psychiatric sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 4 pooled it
22.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 4 syntheses or guidelines pooled it, 123 citations in OpenAlex.

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  6. Exposome factors predict the association between sleep health and depression.medRxiv : the preprint server for health sciences · 2026
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Xiaohui SunDepartment of Epidemiology and Biostatistics, School of Public Health, Zhejiang Chinese Medical University, Hangzhou310053, China.
Bin LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Zhejiang Chinese Medical University, Hangzhou310053, China.
Sitong LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Zhejiang Chinese Medical University, Hangzhou310053, China.
David J H WuDepartment of Internal Medicine, University of Minnesota-Twin Cities Medical School, Minneapolis, MN, USA.
Jianming WangDepartment of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, NJ08901, USA.
Yi QianDepartment of Epidemiology and Biostatistics, School of Public Health, Zhejiang Chinese Medical University, Hangzhou310053, China.
Ding YeDepartment of Epidemiology and Biostatistics, School of Public Health, Zhejiang Chinese Medical University, Hangzhou310053, China.
Yingying MaoDepartment of Epidemiology and Biostatistics, School of Public Health, Zhejiang Chinese Medical University, Hangzhou310053, China.ORCID https://orcid.org/0000-0003-3644-9160
Zhejiang Chinese Medical University · CNRutgers, The State University of New Jersey · USUniversity of Minnesota · US

Funding

Foundation of Zhejiang Chinese Medical University Foundation of Zhejiang Chinese Medical University
6 · The paper itself

Abstract

aimsSleep disturbance is an important factor in the pathophysiology and progression of psychiatric disorders, but whether it is a cause, or a downstream effect is still not clear.

methodsTo investigate causal relationships between three sleep-associated traits and seven psychiatric diseases, we used genetic variants related to insomnia, chronotype and sleep duration to perform a two-sample bidirectional Mendelian randomisation analysis. Summary-level data on psychiatric disorders were extracted from the Psychiatric Genomics Consortium. Effect estimates were obtained by using the inverse-variance-weighted (IVW), weights modified IVW, weighted-median methods, MR-Egger regression, MR pleiotropy residual sum and outlier (MR-PRESSO) test and Robust Adjusted Profile Score (RAPS).

resultsThe causal odds ratio (OR) estimate of genetically determined insomnia was 1.33 (95% confidence interval (CI) 1.22-1.45; p = 5.03 × 10-11) for attention-deficit/hyperactivity disorder (ADHD), 1.31 (95% CI 1.25-1.37; p = 6.88 × 10-31) for major depressive disorder (MDD) and 1.32 (95% CI 1.23-1.40; p = 1.42 × 10-16) for post-traumatic stress disorder (PTSD). There were suggestive inverse associations of morningness chronotype with risk of MDD and schizophrenia (SCZ). Genetically predicted sleep duration was also nominally associated with the risk of bipolar disorder (BD). Conversely, PTSD and MDD were associated with an increased risk of insomnia (OR = 1.06, 95% CI 1.03-1.10, p = 7.85 × 10-4 for PTSD; OR = 1.37, 95% CI 1.14-1.64; p = 0.001 for MDD). A suggestive inverse association of ADHD and MDD with sleep duration was also observed.

conclusionsOur findings provide evidence of potential causal relationships between sleep disturbance and psychiatric disorders. This suggests that abnormal sleep patterns may serve as markers for psychiatric disorders and offer opportunities for prevention and management in psychiatric disorders.

Indexed as

Major Depressive DisorderSleep Initiation and Maintenance DisordersSleep Wake DisordersGenome-Wide Association StudyHumansMendelian Randomization AnalysisSleepEpidemiologyevidence-based psychiatryfactor analysispsychosissleep

Identifiers

PMID35465862
PMCPMC9069588
OpenAlexW4224444535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.