Evidence map›Paper›PMID 35465707›Full record

ArticleAntimicrobial agents and chemotherapy2022

Selective Inhibition of Plasmodium falciparum ATPase 6 by Artemisinins and Identification of New Classes of Inhibitors after Expression in Yeast.

Catherine M Moore, Jigang Wang, Qingsong Lin, Pedro Ferreira, Mitchell A Avery, Khaled Elokely, Henry M Staines, Sanjeev Krishna

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Tropical life sciences research · 2025
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Catherine M MooreInstitute for Infection and Immunity, St. George's, University of London, London, United Kingdom.ORCID 0000-0001-6678-6999
Jigang WangDepartment of Biological Sciences, National University of Singaporegrid.4280.e, Singapore, Singapore.
Qingsong LinDepartment of Biological Sciences, National University of Singaporegrid.4280.e, Singapore, Singapore.
Pedro FerreiraMicrobiology and Infection Research Domain, Life and Health Sciences Research Institute, School of Medicine, University of Minho, Campus de Gualtar, Braga, Portugal.
Mitchell A AveryUniversity of Mississippi, School of Pharmacy, Department of BioMolecular Sciences, Division of Medicinal Chemistry, Oxford, Mississippi, USA.
Khaled ElokelyInstitute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania, USA.
Henry M StainesInstitute for Infection and Immunity, St. George's, University of London, London, United Kingdom.
Sanjeev KrishnaInstitute for Infection and Immunity, St. George's, University of London, London, United Kingdom.ORCID 0000-0003-0066-0634
National University of Singapore · SGSt George's, University of London · GBNational Health Service · GBTemple University · USUniversity of Minho · PTUniversity of Mississippi · US

Funding

Wellcome TrustWellcome Trust 204809/Z/16/Z
6 · The paper itself

Abstract

Treatment failures with artemisinin combination therapies (ACTs) threaten global efforts to eradicate malaria. They highlight the importance of identifying drug targets and new inhibitors and of studying how existing antimalarial classes work. Here, we report the successful development of a heterologous expression-based compound-screening tool. The validated drug target Plasmodium falciparum ATPase 6 (PfATP6) and a mammalian orthologue (sarco/endoplasmic reticulum calcium ATPase 1a [SERCA1a]) were functionally expressed in Saccharomyces cerevisiae, providing a robust, sensitive, and specific screening tool. Whole-cell and

Indexed as

AntimalarialsArtemisininsMalaria, FalciparumAnimalsCalcium-Transporting ATPasesDrug ResistanceMammalsPlasmodium falciparumSaccharomyces cerevisiaeAntimalarialsArtemisininsCalcium-Transporting ATPasesantimalarial agentsdrug discoverydrug resistance mechanismsdrug screeningmechanisms of actionSaccharomyces cerevisiae

Identifiers

PMID35465707
PMCPMC9112895
OpenAlexW4224312819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.