Evidence map›Paper›PMID 35465650›Full record

ArticleMagnetic resonance (Gottingen, Germany)2021

Overhauser dynamic nuclear polarization (ODNP)-enhanced two-dimensional proton NMR spectroscopy at low magnetic fields.

Timothy J Keller, Thorsten Maly

Abstract read
In one paragraph

Article in Magnetic resonance (Gottingen, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Optical Hyperpolarization of 1H and 19F Spins in Organic Liquids.The journal of physical chemistry letters · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. LargePhysical chemistry chemical physics : PCCP · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Timothy J KellerBridge12 Technologies Inc., 37 Loring Drive, Framingham, MA 01702, USA.
Thorsten MalyBridge12 Technologies Inc., 37 Loring Drive, Framingham, MA 01702, USA.

Funding

An ODNP Probe to Study Hydration Dynamics in Membrane ProteinR44GM116612 · NIGMS · BRIDGE 12 TECHNOLOGIES, INC. · PI MALY, THORSTEN · 2019 to 2020
$1.2M
Compact, Integrated EPR Spectrometer for Dynamic Nuclear PolarizationR44GM112391 · NIGMS · BRIDGE 12 TECHNOLOGIES, INC. · PI MALY, THORSTEN · 2016 to 2017
$1.1M
A Resonator for Pulsed ODNP Spectroscopy to Study Surface Hydration DynamicsR44GM126770 · NIGMS · BRIDGE 12 TECHNOLOGIES, INC. · PI MALY, THORSTEN · 2021 to 2022
$973k
An ODNP Probe to Study Hydration Dynamics in Membrane ProteinR43GM116612 · NIGMS · BRIDGE 12 TECHNOLOGIES, INC. · PI MALY, THORSTEN · 2015 to 2016
$278k
A Compact Hybrid Magnet with High Homogeneity for X-Band DNP/NMR and EPR SpectroscopyR43GM128542 · NIGMS · BRIDGE 12 TECHNOLOGIES, INC. · PI MALY, THORSTEN, SIRIGIRI, JAGADISHWAR RAO · 2018 to 2018
$232k
A Resonator for Pulsed ODNP Spectroscopy to Study Surface Hydration DynamicsR43GM126770 · NIGMS · BRIDGE 12 TECHNOLOGIES, INC. · PI MALY, THORSTEN · 2018 to 2018
$225k
Compact, Integrated EPR Spectrometer for Dynamic Nuclear PolarizationR43GM112391 · NIGMS · BRIDGE 12 TECHNOLOGIES, INC. · PI MALY, THORSTEN · 2014 to 2014
$186k
NIGMS NIH HHS R43 GM112391NIGMS NIH HHS R43 GM116612NIGMS NIH HHS R43 GM126770NIGMS NIH HHS R43 GM128542NIGMS NIH HHS R44 GM112391NIGMS NIH HHS R44 GM116612NIGMS NIH HHS R44 GM126770
6 · The paper itself

Abstract

The majority of low-field Overhauser dynamic nuclear polarization (ODNP) experiments reported so far have been 1D NMR experiments to study molecular dynamics and in particular hydration dynamics. In this work, we demonstrate the application of ODNP-enhanced 2D J-resolved (JRES) spectroscopy to improve spectral resolution beyond the limit imposed by the line broadening introduced by the paramagnetic polarizing agent. Using this approach, we are able to separate the overlapping multiplets of ethyl crotonate into a second dimension and clearly identify each chemical site individually. Crucial to these experiments is interleaved spectral referencing, a method introduced to compensate for temperature-induced field drifts over the course of the NMR acquisition. This method does not require additional hardware such as a field-frequency lock, which is especially challenging when designing compact systems.

Identifiers

PMID35465650
PMCPMC9030190

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.