Evidence map›Paper›PMID 35465434›Full record

ArticleFrontiers in surgery2022

Efficacy and Safety of Novel Beta-Chitin Patches as Haemostat in Rat Vascular and Neurosurgical Model.

Ahad Sabab, Rajan Sundaresan Vediappan, John Finnie, C John McAdam, Alistair Jukes, Sarah Vreugde, Peter-John Wormald

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ahad SababDepartment of Surgery-Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, SA, Australia.
Rajan Sundaresan VediappanDepartment of Surgery-Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, SA, Australia.
John FinnieDiscipline of Anatomy and Pathology, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
C John McAdamDepartment of Chemistry, University of Otago, Dunedin, New Zealand.
Alistair JukesDepartment of Surgery-Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, SA, Australia.
Sarah VreugdeDepartment of Surgery-Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, SA, Australia.
Peter-John WormaldDepartment of Surgery-Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, SA, Australia.
University of Adelaide · AUUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Intraoperative hemorrhage is a major cause of poor post-operative outcome. Beta-chitin patch has previously been found to be an effective haemostat, but whether modifying the patch can improve its efficacy and safety, remains unknown. In this study, beta-chitin patches were modified using polyethylene oxide, Pluronic-F127 (Chi/F127), calcium (Chi/20%Ca), increased thickness (Chi/Thick) or polyphosphate (Chi/PP). Objective: Using rat (Wistar Albino; 8-10 weeks old) vascular and neurosurgical models, this project investigated and compared the efficacy and safety of beta-chitin patches with gauze, Surgicel and FloSeal. Methods: Ninety rats underwent a standardized femoral artery injury and were randomized to receive either beta-chitin patches, gauze, Surgicel or FloSeal. The bleeding time and total blood loss was measured. For the neurosurgical model, forty-four rats underwent a standardized cortical injury and randomization to a treatment group. Following a 48 h recovery period, their brains were collected for histopathological examination. Results: The mean bleeding time with Chitin (120.8 s) and Chi/PP (117.3 s) was ~60 s lower than Chi/F127, Chi/20%Ca and Chi/Thick ( Conclusion: Chi/PP had superior haemostatic efficacy compared to Surgicel and FloSeal, but not compared to non-modified beta-chitin patch. All of the haemostats were equally safe.

Indexed as

bio-technologychitinhaemostasishaemostatneurosurgeryp-GlcNAc

Identifiers

PMID35465434
PMCPMC9023757
OpenAlexW4226145685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.