Evidence map›Paper›PMID 35465352›Full record

ArticleJournal of immunology research2022

Oral S2-Ag85 DNA Vaccine Activated Intestinal Cell dsDNA and RNA Sensors to Promote the Presentation of Intestinal Antigen.

Dang Sheng, Sui Xin, Wu Dongxing, Wen Shubo, Song Yang, Chen Zeliang, Zhai Jingbo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. An SNP-based diagnostic method forFrontiers in veterinary science · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dang ShengInnovative Institute of Zoonoses, Inner Mongolia Minzu University, Tongliao 028000, China.
Sui XinInnovative Institute of Zoonoses, Inner Mongolia Minzu University, Tongliao 028000, China.
Wu DongxingInnovative Institute of Zoonoses, Inner Mongolia Minzu University, Tongliao 028000, China.
Wen ShuboInnovative Institute of Zoonoses, Inner Mongolia Minzu University, Tongliao 028000, China.
Song YangInnovative Institute of Zoonoses, Inner Mongolia Minzu University, Tongliao 028000, China.
Chen ZeliangInnovative Institute of Zoonoses, Inner Mongolia Minzu University, Tongliao 028000, China.
Zhai JingboInnovative Institute of Zoonoses, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID https://orcid.org/0000-0001-8891-279X
Inner Mongolia University for Nationalities · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the molecular mechanism by which oral S2-Ag85DNA vaccines present intestinal antigens. The oral S2-Ag85 vaccine has been shown to protect the human body and effectively improve the titration of the vaccine by acting on intestinal mucosa cells and enhancing their immunogenicity. Method: Mice were immunized with the recombinant S2-Ag85 vaccine, and antibody secretion was then detected in the intestinal tissue. The molecular mechanisms of Results: The S2-Ag85A vaccine was effective in activating dsDNA and RNA transduction pathways in intestinal cells and improving intestinal antigen presentation in mice.

Indexed as

Vaccines, DNAAnimalsAntigens, BacterialIntestinesMiceRNAAntigens, BacterialRNAVaccines, DNA

Identifiers

PMID35465352
PMCPMC9020918
OpenAlexW4223954143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.