Evidence map›Paper›PMID 35464963›Full record

ArticleFrontiers in microbiology2022

Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis.

Yan Xie, Li Yang, Pengfei Cao, Shen Li, Wentao Zhang, Wei Dang, Shuyu Xin, Mingjuan Jiang, Yujie Xin, Jing Li and 5 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Yan XieDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Li YangDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Pengfei CaoDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Shen LiDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Wentao ZhangDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Wei DangDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Shuyu XinDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Mingjuan JiangDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Yujie XinDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Jing LiDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Sijing LongDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Yiwei WangDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Senmiao ZhangDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Yang YangDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Jianhong LuDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNXiangya Hospital Central South University · CNNational Health and Family Planning Commission · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening syndrome, which is caused by EBV infection that is usually refractory to treatment and shows relapse. The development of new biomarkers for the early diagnosis and clinical treatment of EBV-HLH is urgently needed. Exosomes have been shown to mediate various biological processes and are ideal non-invasive biomarkers. Here, we present the differential plasma exosomal proteome of a patient with EBV-HLH before vs. during treatment and with that of his healthy twin brother. A tandem mass tag-labeled LC-MS technique was employed for proteomic detection. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that differential proteomic profiles were related to virus infection, coagulopathy, nervous system dysfunction, imbalance of immune response, and abnormal liver function. The candidate biomarkers were first identified in the patient's plasma exosomes at different treatment and follow-up time points. Then, 14 additional EBV-HLH exosome samples were used to verify six differentially expressed proteins. The upregulation of C-reactive protein, moesin, galectin three-binding protein, and heat shock cognate 71 kDa protein and the downregulation of plasminogen and fibronectin 1 could serve as potential biomarkers of EBV-HLH. This plasma exosomal proteomic analysis provides new insights into the diagnostic and therapeutic biomarkers of EBV-HLH.

Indexed as

biomarkerEpstein-Barr virusexosomeshemophagocytic lymphohistiocytosisquantitative proteomics

Identifiers

PMID35464963
PMCPMC9019563
OpenAlexW4226175713

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.