Evidence map›Paper›PMID 35464469›Full record

ArticleFrontiers in immunology2022

CD39 and CD326 Are Bona Fide Markers of Murine and Human Plasma Cells and Identify a Bone Marrow Specific Plasma Cell Subpopulation in Lupus.

Van Duc Dang, Elodie Mohr, Franziska Szelinski, Tuan Anh Le, Jacob Ritter, Timo Hinnenthal, Ana-Luisa Stefanski, Eva Schrezenmeier, Soeren Ocvirk, Christian Hipfl and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Distinct autoreactive CD19Nature communications · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Temporal Tracking of Plasma CellsbioRxiv : the preprint server for biology · 2023
    Article
  6. From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Van Duc DangDeutsches Rheuma-Forschungszentrum, A Leibniz Institute, Berlin, Germany.
Elodie MohrDeutsches Rheuma-Forschungszentrum, A Leibniz Institute, Berlin, Germany.
Franziska SzelinskiDeutsches Rheuma-Forschungszentrum, A Leibniz Institute, Berlin, Germany.
Tuan Anh LeDeutsches Rheuma-Forschungszentrum, A Leibniz Institute, Berlin, Germany.
Jacob RitterDepartment of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Timo HinnenthalDeutsches Rheuma-Forschungszentrum, A Leibniz Institute, Berlin, Germany.
Ana-Luisa StefanskiDepartment of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Eva SchrezenmeierBerlin Institute of Health (BIH), Berlin, Germany.
Soeren OcvirkIntestinal Microbiology Research Group, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Christian HipflCentre for Musculoskeletal Surgery, Department of Orthopedics, Charité Universitätsmedizin Berlin, Berlin, Germany.
Sebastian HardtCentre for Musculoskeletal Surgery, Department of Orthopedics, Charité Universitätsmedizin Berlin, Berlin, Germany.
Qingyu ChengDeutsches Rheuma-Forschungszentrum, A Leibniz Institute, Berlin, Germany.
Falk HiepeDeutsches Rheuma-Forschungszentrum, A Leibniz Institute, Berlin, Germany.
Max LöhningDeutsches Rheuma-Forschungszentrum, A Leibniz Institute, Berlin, Germany.
Thomas DörnerDeutsches Rheuma-Forschungszentrum, A Leibniz Institute, Berlin, Germany.
Andreia C LinoDeutsches Rheuma-Forschungszentrum, A Leibniz Institute, Berlin, Germany.
German Rheumatism Research Centre · DECharité - Universitätsmedizin Berlin · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEGerman Institute of Human Nutrition · DEVietnam National University, Hanoi · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibody-secreting cells (ASCs) contribute to immunity through production of antibodies and cytokines. Identification of specific markers of ASC would allow selective targeting of these cells in several disease contexts. Here, we performed an unbiased, large-scale protein screening, and identified twelve new molecules that are specifically expressed by murine ASCs. Expression of these markers, particularly CD39, CD81, CD130, and CD326, is stable and offers an improved resolution for ASC identification. We accessed their expression in germ-free conditions and in T cell deficient mice, showing that at least in part their expression is controlled by microbial- and T cell-derived signals. Further analysis of lupus mice revealed the presence of a subpopulation of LAG-3

Indexed as

Bone MarrowPlasma CellsAnimalsAntibodies, AntinuclearAntibody-Producing CellsBiomarkersHumansImmunoglobulin MMiceAntibodies, Antinuclearanti-dsDNA autoantibodyBiomarkersImmunoglobulin MCD130CD326CD39CD81LAG-3plasma cell markersplasma cellsSLE

Identifiers

PMID35464469
PMCPMC9024045
OpenAlexW4225592283

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.